Results 181 to 190 of about 40,039 (253)

Strain‐based characterization of atrioventricular and left atrial remodelling in rat models of heart failure with preserved ejection fraction

open access: yesExperimental Physiology, EarlyView.
Abstract Current experimental models of heart failure with preserved ejection fraction (HFpEF) lack standardized approaches for evaluating left atrial (LA) remodelling and atrioventricular (AV) coupling, leaving a critical gap in mechanistic understanding and phenotypic characterization. This study aimed to explore LA function and AV coupling status in
Qingfeng Zhang   +4 more
wiley   +1 more source

Identification of the individual cardiac contraction threshold during high‐frame‐rate stress echocardiography

open access: yesExperimental Physiology, EarlyView.
Abstract The clinical assessment of cardiovascular function during exercise using stress echocardiography is essential for accurate cardiac diagnosis. However, normal limitations of cardiac deformation responses to increasing physical exertion remain poorly understood.
Fabian Spahiu   +4 more
wiley   +1 more source

Advances in cardiac devices and bioelectronics augmented with artificial intelligence

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Interfaces between the human heart, diagnostic bioelectronics, artificial intelligence, and clinical care. From left to right: Human heart and biosensor interface; representative waveforms of common diagnostic bioelectronic sensing modalities.
Charles Stark   +3 more
wiley   +1 more source

Enhancing stroke risk stratification in atrial fibrillation through non‐Newtonian blood modelling and Gaussian process emulation

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Non‐Newtonian modelling and GPEs for stroke risk in atrial fibrilation patients. Abstract Atrial fibrillation (AF) is the most common heart arrhythmia, linked to a five‐fold increase in stroke risk. The left atrial appendage (LAA), prone to blood stasis, is a common thrombus formation site in AF patients.
Paolo Melidoro   +12 more
wiley   +1 more source

Virtual left atrial appendage occlusion in paroxysmal atrial fibrillation during sinus rhythm predicts variable reductions in blood stasis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Stasis before and after left atrial appendage occlusion (LAAO) in participants with high stasis and low stasis. Stasis is predominantly located in LAA and reduced after LAAO. But in the participant with high stasis, stasis remains close to the occlusion site, indicating a potential risk for device related thrombi.
Sophia Bäck   +6 more
wiley   +1 more source

In silico predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging‐based fibrotic left ventricle models

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero   +7 more
wiley   +1 more source

Determinants of maximal oxygen uptake in highly trained females and males: a mechanistic study of sex differences using advanced invasive methods

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The results from this study show that maximal cardiac output, stroke volume and leg blood flow are similar between highly trained females and males after normalisation to lean body mass (LBM). However, the 10% higher haemoglobin concentration ([Hb]) and arterial O2 content in males result in higher systemic and leg O2 delivery ...
Øyvind Skattebo   +11 more
wiley   +1 more source

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