Results 31 to 40 of about 24,415 (312)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Discovery and antitumor evaluation of novel inhibitors of spermine oxidase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Increasing knowledge of the relationship between cancer and dysregulated polyamine catabolism suggests interfering with aberrant polyamine metabolism for anticancer therapy that will have considerable clinical promise.
Lidan Sun, Jianlin Yang, Yu Qin, Yanlin Wang, Hongyan Wu, You Zhou, Chunyu Cao   +6 more
doaj   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Analysis of the learning curve for unilateral biportal endoscopic technique using CUSUM method on fresh frozen cadavers

BMC Musculoskeletal Disorders
Purpose This study aims to determine the learning curve for lumbar discectomy and nerve root decompression using the unilateral biportal endoscopic (UBE) technique on fresh frozen cadavers through linear regression and cumulative sum (CUSUM) analyses ...
Han Wang, Xinzhi Li, Bo Li, Junsheng Du, Zenan Meng, Wenyao Chen, Xiangyong Que, Chongyu Huang, Yi Li, Jie Wang, Abulimiti Mireadeli   +10 more
doaj   +1 more source

Multivariate Dam-Site Flood Frequency Analysis of the Three Gorges Reservoir Considering Future Reservoir Regulation and Precipitation [PDF]

, 2022
Lihua Xiong, Cong Jiang, Shenglian Guo, Shuai Li, Rongrong Li, Wenbin Li   +5 more
openalex   +1 more source

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, EarlyView.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Angewandte Chemie, EarlyView.
Electrostatically layered nanoparticles (NPs) coated with anionic polypeptides selectively target cancer cells by engaging amino acid transporters. Poly(L‐glutamate) (PLE) coatings cluster the glutamine transporter SLC1A5, prolonging NP surface retention, while poly(L‐aspartate) (PLD) coatings also bind SLC1A3, potentially promoting faster ...
Ivan S. Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering, Eva Cai, Gonzalo J. Esparza, Mae L. Pryor, Alexander D. Stoneman, Aidan Kindopp, Darrell J. Irvine, Paula T. Hammond   +10 more
wiley   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Unsupervised Graph‐Based Deep Clustering for Optimal Monitoring Point Placement in Urban Drainage Networks

Engineering Reports
The optimal placement of monitoring points in urban drainage networks is critical for operational efficiency, yet traditional methods suffer from high costs and redundancy.
Yaole Qi, Qiang Li, Guangrong Cao, Gang Li, Lei Zhang, Bo Yang   +5 more
doaj   +1 more source

MDFANet: Multidimensional Feature Alignment Network for Self-Supervised Pretraining in Remote Sensing Change Detection

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Recently, self-supervised pretraining algorithms have been extensively investigated in the field of remote sensing, yielding significant performance improvements in change detection tasks. However, many existing algorithms inadequately exploit multilevel
Lu Wang, Chenyang Wang, Runzhou Li, Junbo Yu, Hang Sun, Wenbin Wang, Dong Ren   +6 more
doaj   +1 more source