Results 41 to 50 of about 24,415 (312)

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Analysis of Failure Models and Deformation Evolution Process of Geological Hazards in Ganzhou City, China

Frontiers in Earth Science, 2021
In Ganzhou City, China, a complex bedrock lithology and structure, diverse topography, frequent engineering works, and abundant rainfall generate frequent, sudden, small-scale landslides that are difficult to prevent and control.
Qinghua Zhan, Qinghua Zhan, Shimei Wang, Shimei Wang, Li Wang, Li Wang, Fei Guo, Fei Guo, Daipeng Zhao, Jinzhou Yan, Jinzhou Yan   +10 more
doaj   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

AlF3 Mediated In‐Situ Cathode Interface Stabilization Enables High‐Rate and Long‐Life Na‐Ion Batteries at Elevated Temperature

Advanced Science, EarlyView.
Ultrathin AlF3 coating facilitates the formation of an inorganic‐dominated cathode electrolyte interphase (CEI), predominantly composed of NaF/AlF3/NaAlF4. This CEI layer effectively suppresses detrimental interfacial side reactions while simultaneously enhancing the diffusion kinetics of Na+.
Ya‐Meng Yin, Qinxia Liu, Zhiyuan Zhang, Weixiao Wang, Cunyuan Pei, Fangyu Xiong, Jinghui Chen, Qinyou An, Cai‐Hong Yang, Dong‐Sheng Li   +9 more
wiley   +1 more source

Regulatory effects of saponins from Panax japonicus on colonic epithelial tight junctions in aging rats

Journal of Ginseng Research, 2018
Background: Saponins from Panax japonicus (SPJ) are the most abundant and main active components of P. japonicus, which replaces ginseng roots in treatment for many kinds of diseases in the minority ethnic group in China.
Yaoyan Dun, Min Liu, Jing Chen, Danli Peng, Haixia Zhao, Zhiyong Zhou, Ting Wang, Chaoqi Liu, Yuhui Guo, Changcheng Zhang, Ding Yuan   +10 more
doaj   +1 more source

Analysis of Contact Characteristics of Carbon Brush/Slip Ring under Eccentric Oscillation of Hydrogenerator Rotor

Shock and Vibration, 2021
In this paper, the contact characteristics of the carbon brush/slip ring of the hydrogenerator under the eccentric vibration of the rotor are studied.
Xinze Zhao, Yunfeng Nie, Ming Chen, Hongling Qin, Xiang Xu   +4 more
doaj   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science, EarlyView.
Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
wiley   +1 more source

Three Gorges Project Resettles Employment Willingness and Behavior Mechanism: A Grounded Theory Approach

SAGE Open, 2022
The construction of hydropower projects has resulted in a significant number of reservoir displacements. Resettlement is unavoidably going to be a difficult problem to solve.
Jin Huang, Ye Tian, Mengfei Song, Ribesh Khanal, Min An   +4 more
doaj   +1 more source