Results 121 to 130 of about 31,735,618 (294)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Are environmental factors for atopic eczema in ISAAC phase three due to reverse causation?

, 2019
: Some previously described environmental associations for atopic eczema may be due to reverse causation. We explored the role of reverse causation by comparing individual-and school-level results for multiple atopic eczema risk factors.
Cepeda, A. M., Barba, S., Riikjarv, M-A, Bhave, S., Beasley, R., Gomez, M., Onadeko, B. O., Rennie, D., Del-Rio-Navarro, B. E., Flohr, C., Setty, G., Romieu, I, Amarales, L., al-Momen, J. A., MacKay, R., Konthen, P., de Freitas Souza, L., Joshi, M. K., Sukumaran, T., Howitt, M. E., Imanalieva, C., Ramirez-Chanona, N., Koffi, B. N., Merida-Palacio, J., V, Singh, V, Shah, J., Standring, P., Bjorksten, B., Asher, M., I, Ellwood, Philippa, Bustos, C., Barragan-Meijueiro, M., Asher, Innes, Suprihati, W., Ordonez, G. A., Jain, K. C., Rego, S., Lee, B. W., Cua-Lim, F., Ellwood, E., Pattemore, P., Lai, C. K., Chiarella, P., Bouayad, Z., Pearce, Neil, Tuuau-Potoi, N., Cukier, G., Khatav, V. A., Silverwood, Richard J., Awasthi, S., Rutter, Charlotte E., Aguirre, V, Robertson, C. F., Sabir, M., Weiland, S. K., Strachan, D., Foliaki, S., Pherwani, A., V, Kartasasmita, C. B., Langan, Sinead M., Keil, U., Weyler, Joost J., Mantri, S. N., Clayton, T. O., Sa'aga-Banuve, R., Sears, M., Linares-Zapien, F. J., Odhiambo, J., Brunekreef, B., Aguilar, P., Sole, D., Benavides, L. A., von Mutius, E., da Cunha, A. J., Hanumante, N. M., Kunii, O., Strachan, David P., Zsigmond, G., Williams, Hywel C., Kudzyte, J., Garcia-Almaraz, R., Wong, G., Gonzalez-Diaz, S. N., Pearce, N., Baena-Cagnani, C. E., Contreras, A., Nishima, S., Pekkanen, J., Garcia-Marcos, Luis, Garcia-Marcos, L., Hypolite, I. E., Chen, Y-Z, Ait-Khaled, N., Anderson, R., Forastiere, F., Aristizabal, G., Anderson, H. R., de Bruyne, J., Mallol, J., Novak, Z., Odajima, H., Baeza-Bacab, M., Kuaban, C., Ferguson, A., Crane, J., Williams, H. C., Lai, C. K. W., Quah, B. S., Montefort, S., Sharma, S. K., Pinto-Vargas, R., Pan, Q. Li, Masjedi, M. R., Melaku, K., Babu, P. S. Suresh, Moyes, C., Weinmayr, G., Romero-Tapia, S., Zhong, N. S., Teh, K. H., Breborowicz, A., Baratawidjaja, K., El Sony, A., Ellwood, P., Salvi, S., Steriu, A., Stewart, A. W., Mitchell, E. A.   +127 more
core  

Noninvasive condition monitoring of three-phase four-wire inverter system parameters

International Journal of Electrical Power & Energy Systems
Current condition monitoring of three-phase inverters is mainly for DC-link capacitance, with little attention paid to AC-side parameters, and some of these methods require the addition of DC current sensors or changes in operating conditions.
Yuan Sun, Jie Chen, Xiaoteng Dai, Ruichang Qiu   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Parent fees - a guide for families.

, 2005
Electronic data.; Title from PDF caption (viewed Feb 16, 2007).; "October, 2005.
Connecticut Birth to Three System.
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Analysis of Output Current Ripple of Three-phase PWM Inverter under Discontinuous Modulation Techniques [PDF]

, 2010
In this paper, an analysis of output current ripple of three-phase PWM inverters with discontinuous modulation is presented. The analytical expressions for discontinuous modulation injection signal are derived.
Dahono, Pekik Argo
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source