Results 1 to 10 of about 18,606 (197)
Thrita, 2016 Background: Multiple drug resistance in breast cancer patients is one of the most important problems when it comes to the treat- ment of this disease. In this regard, polymorphisms in DNA sequences play a key role in pharmacokinetics and pharmacodynamics.
Hussain Ahmad +4 more
semanticscholar +4 more sources
Comparative analysis of the base compositions of the pre-mRNA 3' cleaved-off region and the mRNA 3' untranslated region relative to the genomic base composition in animals and plants. [PDF]
PLoS ONE, 2014 The precursor messenger RNA (pre-mRNA) three-prime cleaved-off region (3'COR) and the mRNA three-prime untranslated region (3'UTR) play critical roles in regulating gene expression.
Xiu-Qing Li
doaj +2 more sources
Advanced Science, 2022 MicroRNAs (miRNAs) are involved in the regulation of gene expression via incomplete base pairing to sequence motifs at the three prime untranslated regions (3′‐UTRs) of mRNAs and play critical roles in the etiology of cancers.
Ning Zhang +15 more
doaj +2 more sources
dbCNV: deleteriousness-based model to predict pathogenicity of copy number variations
BMC Genomics, 2023 Background Copy number variation (CNV) is a type of structural variation, which is a gain or loss event with abnormal changes in copy number. Methods to predict the pathogenicity of CNVs are required to realize the relationship between these variants and
Kangqi Lv +6 more
doaj +2 more sources
The Iraqi Journal of Agricultural science, 2021 The estrogen receptor 2 (ESR2) plays a crucial role in the growth and development of follicles and ovulation in chickens. The aim of this study was detect the association of estrogen receptor 2(ESR2) gene polymorphisms with the production performance of ...
R.. I. A. Abu-Rekaiba +2 more
doaj +2 more sources
Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5. [PDF]
PLoS Pathogens, 2016 The mechanisms underlying human cytomegalovirus (HCMV) latency remain incompletely understood. Here, we showed that a HCMV-encoded miRNA, miR-UL148D, robustly accumulates during late stages of experimental latent HCMV infection in host cells and promotes
Chaoyun Pan +7 more
doaj +2 more sources
Association of a bovine prion gene haplotype with atypical BSE. [PDF]
PLoS ONE, 2008 BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with
Michael L Clawson +7 more
doaj +2 more sources
Frontiers in Genetics, 2020 Adipose tissue is the largest energy reservoir and secretory organ in the animal body, and is essential for maintaining normal physiological functions and metabolic balance.
Li Wang +8 more
doaj +2 more sources
MicroRNA-150 enhances radiosensitivity by inhibiting the AKT pathway in NK/T cell lymphoma
Journal of Experimental & Clinical Cancer Research, 2018 Background Radioresistance is a major challenge during the treatment of NK/T cell lymphoma. This study aimed to investigate the potential role of MicroRNA-150 (miR-150) in increase the sensitivities of NK/T cell lymphoma to ionizing radiation. Results In
Shao Jie Wu +4 more
doaj +2 more sources
Plus-strand RNA viruses hijack Musashi homolog 1 to shield viral RNA from cytoplasmic ribonuclease degradation. [PDF]
J VirolA successful strategy employed by RNA viruses to achieve replication is to evade host cell RNase degradation. However, the mechanisms through which plus-strand RNA viruses effectively shield viral RNA from cellular ribonuclease degradation remain unclear.
Zhou D +13 more
europepmc +2 more sources