Preferential superficial cortical layer activation during seizure propagation
Epilepsia, Volume 66, Issue 3, Page 929-941, March 2025.Abstract Objective Focal cortical seizures travel long distances from the onset zone, but the long‐distance propagation pathways are uncertain. In vitro and in vivo imaging techniques have investigated the local spread of seizures but did not elucidate long‐distance spread. Furthermore, classical studies in slices suggested seizure spread locally along
Anastasia Brodovskaya +4 more
wiley +1 more source
Genetic characteristics of novel extreme alkaline-inducible promoter located in five prime upstream region of peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum. [PDF]
Sci RepKim DG, Kim GM, Oh DN, Kim YS, Lee JM.
europepmc +1 more source
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
The FEBS Journal, EarlyView.Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser +9 more
wiley +1 more source
A single-dose mRNA vaccine encoding the classical swine fever virus E2-ECD induces durable protective immunity in rabbits. [PDF]
Vet ResBian LJ +11 more
europepmc +1 more source
Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock
The FEBS Journal, EarlyView.Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány +6 more
wiley +1 more source
Comprehensive approaches to design efficient gRNA for SDN1-CRISPR/Cas9 genome editing in wheat. [PDF]
Front Genome EdSingh T +8 more
europepmc +1 more source
Human FASTK preferentially binds single‐stranded and G‐rich RNA
The FEBS Journal, EarlyView.Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source
UTRGAN: learning to generate 5' UTR sequences for optimized translation efficiency and gene expression. [PDF]
Bioinform AdvBarazandeh S +4 more
europepmc +1 more source
The FEBS Journal, EarlyView.Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan +5 more
wiley +1 more source
Infantile myofibromatosis and capillary malformation of the skin due to PDGFRB mosaicism. [PDF]
Mol Cell PediatrPudig L +7 more
europepmc +1 more source