Results 101 to 110 of about 18,606 (197)

TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells

The FEBS Journal, EarlyView.
TSC22D1 acts downstream of glucose signaling and negatively regulates insulin secretion in pancreatic beta cells. Mechanistically, TSC22D1 interacts with FoxO1. Elevated glucose levels enhance the TSC22D1–FoxO1 interaction indirectly by increasing the protein abundance of TSC22D1. Importantly, TSC22D1 and FoxO1 not only physically associate but also co‐
Sümbül Yıldırım, Amit Mhamane, Svenja Lösch, Annika Wieder, Ezgi Ermis, Ann‐Christine König, Sevgican Yilmaz, Stefanie M. Hauck, Fatih Kocabas, Julia Szendroedi, Stephan Herzig, Bilgen Ekim   +11 more
wiley   +1 more source

A directionally evolved genomic feature in BRSK2 harbors divergent alleles in neurocognitive disorders. [PDF]

Sci Rep
Ohadi M, Bayat H, Khamse S, Delbari A, Arabfard M.   +4 more
europepmc   +1 more source

Self‐Consumption Translation: Exploring Interlingual Translation Within Multilingual (mainland) China

International Journal of Applied Linguistics, EarlyView.
ABSTRACT Interlingual translation, as defined by Roman Jakobson, refers to the transfer of meaning between languages. However, this concept has often been conflated with linguistic shifts between distinct cultures and nation‐states. To challenge this misconception, I propose the concept of self‐consumption translation (SCT), a subfield of interlingual ...
Bilin (Belen) Liu
wiley   +1 more source

Complete genome sequences of nine double recombinant vaccine-derived novel oral poliovirus type 2 genomes from Nigeria 2023-2024. [PDF]

Microbiol Resour Announc
Castro CJ, Oderinde BS, Poston KD, Mawashi KY, Bullard K, Akinola M, Meade C, Liu H, Hu F, Bullows JE, Gonzalez Z, Pang H, Sarris S, Agha C, Dybdahl-Sissoko N, Perry DB, McDuffie L, Henderson E, Burns CC, Jorba J, Baba M.   +20 more
europepmc   +1 more source

Extracellular vesicles from adipose‐derived mesenchymal stem cells prevent high glucose‐induced retinal ganglion cell pyroptosis through a microRNA‐26a‐5p‐dependent mechanism

Journal of Diabetes Investigation, EarlyView.
ADSC‐EVs carrying miR‐26a‐5p confer protection against RGC pyroptosis by targeting HDAC4 and activating H3K27ac‐dependent Nrf2 expression. ABSTRACT Objective Mesenchymal stromal/stem cells have neuroprotective effects that limit damage to the retina, which is predominantly mediated by the released extracellular vesicles (EVs).
Lei Tang, Jian Zhang, Jianping Gao
wiley   +1 more source

Hammerhead Ribozymes: Structural Insights, Catalytic Mechanisms, and Cutting-Edge Applications in Synthetic Biology. [PDF]

Int J Mol Sci
Wang L, Liu Y, Xian X, Zhang H.
europepmc   +1 more source

Gaining insights into epigenetic memories through artificial intelligence and omics science in plants

Journal of Integrative Plant Biology, EarlyView.
This review explores how artificial intelligence and machine learning predict plant behavior in response to environmental stress by modeling molecular regulatory networks of plant stress responses. Their combined application with omics methods opens new avenues in understanding the functioning of plant memory and future plant memory‐based plant ...
Judit Dobránszki, Valya Vassileva, Dolores R. Agius, Panagiotis Nikolaou Moschou, Philippe Gallusci, Margot M.J. Berger, Dóra Farkas, Marcos Fernando Basso, Federico Martinelli   +8 more
wiley   +1 more source

Complete genome sequence and characterisation of a novel flexivirus infecting the necrotrophic conifer pathogen Diplodia sapinea. [PDF]

Arch Virol
Sutela S, Trifković M, Terhonen E.
europepmc   +1 more source

Evidence that genetic drift not adaptation drives fast‐Z and large‐Z effects in Ficedula flycatchers

Molecular Ecology, EarlyView.
Abstract The sex chromosomes have been hypothesized to play a key role in driving adaptation and speciation across many taxa. The reason for this is thought to be the hemizygosity of the heteromorphic part of sex chromosomes in the heterogametic sex, which exposes recessive mutations to natural and sexual selection. The exposure of recessive beneficial
Madeline A. Chase, Maurine Vilcot, Carina F. Mugal   +2 more
wiley   +1 more source

Genome characterization of prunus maculavirus 1 (PrMcV-1), a novel member of the genus maculavirus identified in prunus spp. [PDF]

Arch Virol
Abou Kubaa R, Ouro-Djobo A, Stevens KA, Alabi OJ, Al Rwahnih M.   +4 more
europepmc   +1 more source