Results 151 to 160 of about 18,606 (197)
Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.HBV DNA integrates in multiple genes including KMT2B in pancreatic cancer. KMT2B upregulation caused by HBV integration or other mechanisms promotes FYN expression via histone H3K4 trimethylation at its promoter region. Increased FYN expression activates the PI3K/Akt signalling pathway, thus driving PDAC cell proliferation, migration and invasion ...
Mengge Li +16 more
wiley +1 more source
Genetic Improvement of rice Grain size Using the CRISPR/Cas9 System. [PDF]
Rice (N Y)Zhang T, Wang Z, Liu Q, Zhao D.
europepmc +1 more source
Food Science &Nutrition, Volume 13, Issue 8, August 2025.Similarly, polyphenols affect epigenetic marks and reduce oxidative stress and inflammation, both key drivers of PD pathology. Therefore, in this review, we explore how these interventions, individually and in combination, influence epigenetic mechanisms relevant to PD.
Xuenan Cao, Xiantao Cui, Bita Badehnoosh
wiley +1 more source
New T2T assembly of Cryptosporidium parvum IOWA II annotated with Legacy-Compatible Gene identifiers. [PDF]
Sci DataBaptista RP +4 more
europepmc +1 more source
Rapid Identification of DUX4::IGH Fusion in Acute Lymphoblastic Leukemia
eJHaem, Volume 6, Issue 4, August 2025.ABSTRACT Introduction DUX4 is rearranged and overexpressed in a subgroup of acute lymphoblastic leukemia (ALL) with B‐precursor phenotype, with a favorable outcome. Even though characteristic gene expression signature as well as surface expression of CD2/CD371 could be a hallmark of DUX4‐rearranged ALL, actual detection of DUX4 rearrangement is ...
Kyoko Moritani +13 more
wiley +1 more source
Prevalence and impact of molecular variation in the three-prime repair exonuclease 1 TREX1 and its implications for oncology. [PDF]
Hum GenomicsShekfeh M, Konaté MM, Krushkal J.
europepmc +1 more source
Molecular Carcinogenesis, Volume 64, Issue 8, Page 1394-1409, August 2025.ABSTRACT Studies from our lab demonstrated that increasing miR‐200 expression in human triple negative breast cancer (TNBC) reduced tumor growth and metastasis In Vivo. In this study, we found that overexpression of miR‐200s in TNBC cells significantly reduced the expression of JAG1.
Megan Vaz +2 more
wiley +1 more source
A comprehensive allele specific expression resource for the equine transcriptome. [PDF]
BMC GenomicsHeath HD +7 more
europepmc +1 more source
MedComm, Volume 6, Issue 8, August 2025.A natural biological molecule, plumbagin (PLB), suppresses hepatocellular carcinoma via cuproptosis. PLB treatment transcriptionally downregulates the primary hepatic copper exporter, ATP7B, thereby accumulating intracellular copper ions to trigger cuproptosis.
Chuyu Wang +11 more
wiley +1 more source
Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle
FASEB BioAdvances, Volume 7, Issue 8, August 2025.Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn +5 more
wiley +1 more source