Results 181 to 190 of about 34,778 (266)

Loss of METTL3 m6A methyltransferase results in short‐term progression and poor treatment outcome of bladder cancer patients

International Journal of Cancer, Volume 158, Issue 3, Page 763-774, 1 February 2026.
What's new? Bladder cancer exhibits a highly heterogeneous molecular landscape and treatment response. The dysregulation of RNA modifications such as m6A has been involved in cancer initiation and progression. This study comprehensively analyzed the expression of the main catalytic component of the m6A methylation machinery in bladder tumors across one
Katerina‐Marina Pilala, Stella Koroneou, Maria‐Alexandra Papadimitriou, Konstantina Panoutsopoulou, Konstantinos Soureas, Georgios‐Christos Giagkos, Panagiotis Levis, Dimitrios Linardoutsos, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas   +10 more
wiley   +1 more source

Comprehensive approaches to design efficient gRNA for SDN1-CRISPR/Cas9 genome editing in wheat. [PDF]

Front Genome Ed
Singh T, Mamrutha HM, Singh R, Jaiswal JP, Wadhwa Z, Kumar R, Singh O, Ahlawat OP, Tiwari R.   +8 more
europepmc   +1 more source

Construction of Reverse Genetics System for Feline Calicivirus FCV‐BJ616 and Proteomic Analysis

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
This study successfully isolated the FCV‐BJ616 strain derived from cats and established a reverse genetics system. In vivo experiments showed that rFCV‐BJ616 exhibits wild‐type virulence, leading to high fever, weight loss, and multi‐organ lesions in infected cats. Proteomic analysis indicated that both rFCV‐BJ616 and FCV‐BJ616 share similar regulatory
Chunmei Xu, Jingjie Zhao, Hao Liu, Haotian Gu, Xinming Tang, Lin Liang, Jiabo Ding, Shaohua Hou, Xiaomin Zhao, Ruiying Liang   +9 more
wiley   +1 more source

The long 5' UTR of nrdAB modulates mRNA levels, stability, and virulence in Pseudomonas aeruginosa PAO1. [PDF]

Sci Rep
Martínez-Mateos Á, Rubio-Canalejas A, Pedraz L, Torrents E.   +3 more
europepmc   +1 more source

QuickProt: A Fast and Accurate Homology‐Based Protein Annotation Tool for Non‐Model Organisms to Advance Comparative Genomics

Molecular Ecology Resources, Volume 26, Issue 2, February 2026.
ABSTRACT The rapid growth of genome sequencing has outpaced the development of efficient annotation tools, especially for species lacking transcriptome data. To address this challenge, we present QuickProt, a fast, accurate and user‐friendly homology‐based protein annotation tool.
Guisen Chen, Hehe Du, Zhenjie Cao, Ying Wu, Chen Zhang, Yongcan Zhou, Jingqun Ao, Yun Sun, Zihao Yuan   +8 more
wiley   +1 more source

A single-dose mRNA vaccine protects mice from lethal Crimean-Congo hemorrhagic fever virus infection. [PDF]

NPJ Vaccines
Rao J, Li J, Jiang T, Guo W, Zhang X, Zhang Z, Su J, Lu M, Hu X, Liu X, Qu R, Zhu T, Hu C, Liu K, Wang H, Shan C.   +15 more
europepmc   +1 more source

Loss of E3 ligase HvST1 function substantially increases distal crossover frequency

New Phytologist, Volume 249, Issue 3, Page 1325-1341, February 2026.
Summary This study characterizes the function of a grass‐specific E3 ubiquitin ligase, HvST1, in regulating synapsis and crossover (CO) formation during meiosis in barley (Hordeum vulgare). In large‐genome cereals, COs are predominantly restricted to distal chromosomal regions, limiting genetic recombination and breeding flexibility.
Jamie Neil Orr, Sybille Ursula Mittmann, Luke Ramsay, Dominika Lewandowska, Abdellah Barakate, Malcolm Macaulay, Nicola McCallum, Robbie Waugh, Isabelle Colas   +8 more
wiley   +1 more source

Complete genome sequences of nine double recombinant vaccine-derived novel oral poliovirus type 2 genomes from Nigeria 2023-2024. [PDF]

Microbiol Resour Announc
Castro CJ, Oderinde BS, Poston KD, Mawashi KY, Bullard K, Akinola M, Meade C, Liu H, Hu F, Bullows JE, Gonzalez Z, Pang H, Sarris S, Agha C, Dybdahl-Sissoko N, Perry DB, McDuffie L, Henderson E, Burns CC, Jorba J, Baba M.   +20 more
europepmc   +1 more source

Investigation into the molecular mechanism of the antiapoptotic functions of CTCF in breast cancer cells using a proteomics approach [PDF]

, 2009
A Vostrov, CF Méndez-Catalá, D Farrar, E Klenova, E Pugacheva, EM Klenova, F Docquier, F Docquier, I Cherhukhin   +8 more
core   +2 more sources