Results 11 to 20 of about 18,606 (197)

ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration

Cell & Bioscience
Background N6-methyladenosine (m6A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral disc degeneration (IDD), a common cause of low back pain, remains unclear.
Yu Lei, Enyu Zhan, Chao Chen, Yaoquan Hu, Zhengpin Lv, Qicong He, Xuenan Wang, Xingguo Li, Fan Zhang   +8 more
doaj   +2 more sources

ExUTR: a novel pipeline for large-scale prediction of 3′-UTR sequences from NGS data

BMC Genomics, 2017
Background The three prime untranslated region (3′-UTR) is known to play a pivotal role in modulating gene expression by determining the fate of mRNA.
Zixia Huang, Emma C. Teeling
doaj   +2 more sources

The miR-155-5p/<i>FBXO11</i> axis inhibits the progression of gastric cancer via the mTOR pathway. [PDF]

Transl Cancer Res
Background Gastric cancer (GC) is a leading cause of cancer-related death. MicroRNAs (miRNAs or miRs) play a crucial role in the pathology of GC, including cell proliferation, invasion, and metastasis.
Yuan T, Liu H, Li F, Meng Q, Wang Y, Yuan M.   +5 more
europepmc   +2 more sources

Silencing miR-1291-LEFTY2 axis diminishes the myofibroblast activities and reactive oxygen species generation of fibrotic buccal mucosal fibroblasts [PDF]

Journal of Dental Sciences
Background/purpose: Oral submucous fibrosis (OSF) is a potentially malignant disorder characterized by chronic inflammation and excessive collagen deposition, leading to fibrosis in the oral mucosa. This study aimed to explore the contribution of the miR-
Ming-Yung Chou, Shih-Min Wang, Pei-Ling Hsieh, Yi-Wen Liao, Cheng-Chia Yu, Chang-Yi Tsai   +5 more
doaj   +2 more sources

Conformational dynamics of the hepatitis C virus 3'X RNA. [PDF]

RNA
The 3′ end of the hepatitis C virus genome is terminated by a highly conserved, 98 nt sequence called 3′X. This untranslated structural element is thought to regulate several essential RNA-dependent processes associated with infection.
Sperstad PD, Holmstrom ED.
europepmc   +2 more sources

Functional Analysis of Haplotypes in Bovine PSAP Gene and Their Relationship with Beef Cattle Production Traits

Animals, 2020
The purpose of this study was to explore functional variants in the prosaposin (PSAP) three prime untranslated region (3’ UTR) and clarify the relationship between the variants and morphological traits.
Haidong Zhao, Mingli Wu, Xiaohua Yi, Xiaoqin Tang, Pingbo Chen, Shuhui Wang, Xiuzhu Sun   +6 more
doaj   +1 more source

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Carcinogenesis, 2020
N6-methyladenosin (m6A) is one of widespread post-transcriptional mRNA modifications in eukaryotes and the m6A modification plays critical roles in various human cancers.
Hao Sheng, Zhen Li, Shixin Su, Wenjing Sun, Xiaoya Zhang, Leilei Li, Jing Li, Shuangping Liu, Bin Lu, Shuai Zhang, Changliang Shan   +10 more
semanticscholar   +1 more source

LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146

Cancer Cell International, 2021
Background Growing evidence has shown that long noncoding RNA: microRNA: mRNA is implicated in tumor initiation, development, and progression. Long noncoding RNA HAND2-AS1 exhibits anti-cancer effects in diverse cancers.
Liping Shan, Wei Liu, Yunhong Zhan
doaj   +1 more source

The Identification of Alternative Polyadenylation in Stomach Adenocarcinomas Using the Genotype-Tissue Expression Project and the Cancer Genome Atlas– Stomach Adenocarcinoma Profiles

International Journal of General Medicine, 2021
Objective Alternative polyadenylation (APA) is a common mechanism that is present in most human genes and determines the length of the messenger ribonucleic acid (mRNA) three prime untranslated region (3ʹ-UTR), which can give rise to changes in mRNA ...
Jian Li, Wen Chen, Yi Cao, Zhengrong Li
semanticscholar   +1 more source

A Systems Genetics Approach Identified GPD1L and its Molecular Mechanism for Obesity in Human Adipose Tissue

Scientific Reports, 2017
To explore novel molecular mechanisms underlying obesity, we applied a systems genetics framework to integrate risk genetic loci from the largest body mass index (BMI) genome-wide association studies (GWAS) meta-analysis with mRNA and microRNA profiling ...
Hao He, Dianjianyi Sun, Yong Zeng, Ruifeng Wang, Wei Zhu, Shaolong Cao, George A. Bray, Wei Chen, Hui Shen, Frank M. Sacks, Lu Qi, Hong-wen Deng   +11 more
doaj   +1 more source