Results 11 to 20 of about 34,778 (266)

dbCNV: deleteriousness-based model to predict pathogenicity of copy number variations

BMC Genomics, 2023
Background Copy number variation (CNV) is a type of structural variation, which is a gain or loss event with abnormal changes in copy number. Methods to predict the pathogenicity of CNVs are required to realize the relationship between these variants and
Kangqi Lv, Dayang Chen, Dan Xiong, Huamei Tang, Tong Ou, Lijuan Kan, Xiuming Zhang   +6 more
doaj   +2 more sources

MicroRNA-150 enhances radiosensitivity by inhibiting the AKT pathway in NK/T cell lymphoma

Journal of Experimental & Clinical Cancer Research, 2018
Background Radioresistance is a major challenge during the treatment of NK/T cell lymphoma. This study aimed to investigate the potential role of MicroRNA-150 (miR-150) in increase the sensitivities of NK/T cell lymphoma to ionizing radiation. Results In
Shao Jie Wu, Jun Chen, BingYi Wu, Yu Jue Wang, Kun Yuan Guo   +4 more
doaj   +2 more sources

Plus-strand RNA viruses hijack Musashi homolog 1 to shield viral RNA from cytoplasmic ribonuclease degradation

Journal of Virology
A successful strategy employed by RNA viruses to achieve replication is to evade host cell RNase degradation. However, the mechanisms through which plus-strand RNA viruses effectively shield viral RNA from cellular ribonuclease degradation remain unclear.
Defang Zhou, Menglu Xu, Qingjie Liu, Ruixue Xin, Gege Cui, Longying Ding, Xiaoyang Liu, Xinyue Zhang, Tianxing Yan, Jing Zhou, Shuhai He, Liangyu Yang, Bin Xiang, Ziqiang Cheng   +13 more
doaj   +2 more sources

ExUTR: a novel pipeline for large-scale prediction of 3′-UTR sequences from NGS data

BMC Genomics, 2017
Background The three prime untranslated region (3′-UTR) is known to play a pivotal role in modulating gene expression by determining the fate of mRNA.
Zixia Huang, Emma C. Teeling
doaj   +2 more sources

ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration

Cell & Bioscience
Background N6-methyladenosine (m6A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral disc degeneration (IDD), a common cause of low back pain, remains unclear.
Yu Lei, Enyu Zhan, Chao Chen, Yaoquan Hu, Zhengpin Lv, Qicong He, Xuenan Wang, Xingguo Li, Fan Zhang   +8 more
doaj   +2 more sources

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Carcinogenesis, 2020
N6-methyladenosin (m6A) is one of widespread post-transcriptional mRNA modifications in eukaryotes and the m6A modification plays critical roles in various human cancers.
Hao Sheng, Zhen Li, Shixin Su, Wenjing Sun, Xiaoya Zhang, Leilei Li, Jing Li, Shuangping Liu, Bin Lu, Shuai Zhang, Changliang Shan   +10 more
semanticscholar   +1 more source

The Human Pregnancy-Specific Glycoprotein Genes are Tightly Linked on the Long Arm of Chromosome 19 and are Coordinately Expressed [PDF]

, 1990
The pregnancy-specific glycoprotein (PSG) genes encode a group of proteins which are found in large amounts in placenta and maternal serum. In situ hybridization analyses of metaphase chromosomes reveal that all the human pregnancy-specific glycoprotein (
Barnett, Barnett, Barnett, Benton, Bohn, Chan, Chomczynski, Feinberg, Fiddes, Grunert, Hefta, Hinoda, Jean, Kamarck, Khan, Khan, Kolbinger, Lathe, Lin, Maniatis, Neumaier, Niemann, Oikawa, Oikawa, Oikawa, Paxton, Perry, Rooney, Rudert, Sanger, Streydio, Takami, Tatarinov, Thompson, Thompson, Thompson, Watanabe, Watanabe, Willcocks, Zimmermann, Zimmermann   +40 more
core   +1 more source

Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 Hemagglutinin [PDF]

, 1983
The complete nucleotide sequence of the hemagglutinin (HA) gene of the human type B influenza virus B/Singapore/222/79 is presented. Comparison with the only other known sequence of a B hemagglutinin (B/Lee/40) shows that antigenic drift in type B HA ...
Fiers, Walter, Huylebroeck, Danny, Min Jou, Willy, Van Rompuy, Ludo, Verhoeyen, Martine   +4 more
core   +3 more sources

RETRACTED ARTICLE: LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146

Cancer Cell International, 2021
Background Growing evidence has shown that long noncoding RNA: microRNA: mRNA is implicated in tumor initiation, development, and progression. Long noncoding RNA HAND2-AS1 exhibits anti-cancer effects in diverse cancers.
Liping Shan, Wei Liu, Yunhong Zhan
doaj   +1 more source

Ornithine Decarboxylase mRNA is Stabilized in an mTORC1-dependent Manner in Ras-transformed Cells [PDF]

, 2012
Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector pathways. ODC is therefore a potential target in the treatment and prevention of Ras-driven tumours. In
Albig, Barreau, Bhattacharyya, Carracedo, Eulalio, Feith, Feith, Foat, Garneau, Gerner, Grens, Ito, Jacinto, Jian-Ying Wang, Johannes, Kashiwagi, Katsanou, Kawai, Kawai, Kedersha, Kertesz, Lai, Lal, Lan Xiao, Liao, Lisa M. Shantz, Liu, Lorenzini, Manzella, Marderosian, Mazan-Mamczarz, Nowotarski, Origanti, Proud, Rao, Repasky, Rousseau, Sarbassov, Shannon L. Nowotarski, Shantz, Shantz, Sofia Origanti, Song, Suswam, Suzanne Sass-Kuhn, Svitkin, Theresa D. Carr, Tong, Topisirovic, Zhang, Zou, Zou   +51 more
core   +2 more sources