Results 201 to 210 of about 34,778 (266)

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng   +17 more
wiley   +1 more source

Genome-wide identification, characterization and expression profiling of purple acid phosphatases under variable phosphorus regimes in lentil (Lens culinaris Medik.). [PDF]

BMC Plant Biol
Chakraborty A, Das A, Banerjee J.
europepmc   +1 more source

Evaluation of ASC as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton, Joshua A. Kulas, Jiahui Liu, Nidhi Walia, Claudia Rangel‐Barajas, Travis Johnson, Jie Zhang, Kun Huang, Andrew D. Mesecar, Jeffrey L. Dage, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson   +12 more
wiley   +1 more source

A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci. [PDF]

Nat Commun
Taguchi J, Kikuchi M, Jeon H, Shimizu R, Mori H, Ikawa M, Yamada Y, Sato K, Ikeda T, Yamazaki S, Ozawa M.   +10 more
europepmc   +1 more source

Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, Volume 78, Issue 1, Page 209-222, January 2026.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Infantile myofibromatosis and capillary malformation of the skin due to PDGFRB mosaicism. [PDF]

Mol Cell Pediatr
Pudig L, Lassmann S, Jacob S, Nastainczyk-Wulf M, Haak A, Werner M, Kapp FG, Hettmer S.   +7 more
europepmc   +1 more source

A Growth‐Coupled Evolutionary Strategy Enhances Heme Biosynthesis in Saccharomyces cerevisiae

Biotechnology Journal, Volume 21, Issue 1, January 2026.
Graphical Abstract and Lay Summary Introducing a plasmid with a heme‐responsive promoter connected to a growth‐promoting gene into Saccharomyces cerevisiae created a positive feedback loop between intracellular heme levels and cell growth. After 100 h of adaptive evolution, the plasmid was removed, resulting in a mutant strain that exhibited an ...
Seoyoon Bang, Eunbi Kim, Sehyeon Park, Pil Kim   +3 more
wiley   +1 more source

Versatile genome editing using Type I-E CRISPR-Cas3 in rice. [PDF]

Plant Cell Physiol
Saika H, Hara N, Yasumoto S, Muranaka T, Yoshimi K, Mashimo T, Toki S.   +6 more
europepmc   +1 more source

Comprehensive Mapping of Functional Enhancers in Chinese Hamster Ovary Cells

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 196-211, January 2026.
In this study, the authors identified regions with enhancer activity in the CHO cell genome using genome‐wide and targeted STARR‐seq. The analysis revealed thousands of newly identified enhancer sequences, where some of the most active sequences could drive transgene expression at levels similar to or higher than strong viral enhancers.
María Santos, Yusuf B. Johari, Laura Biggins, Natalie C. Elliott, Stefan Schoenfelder, Mounika Boddireddy, Daniel K. Fabian, Michael Anbar, Peter M. O'Callaghan, Peter J. Rugg‐Gunn   +9 more
wiley   +1 more source

Immunological and transcriptomic profile of chimeric live-attenuated Zika vaccine linked to protection in non-human primates. [PDF]

Nat Commun
Ma J, Malengier-Devlies B, Verstrepen BE, Alpizar YA, Vercruysse T, Javarappa MPA, Sanchez-Felipe L, Koopman G, de Groot NG, Matthys P, Neyts J, Verschoor EJ, Coelmont L, Thibaut HJ, Van Weyenbergh J, Dallmeier K.   +15 more
europepmc   +1 more source