Results 211 to 220 of about 34,778 (266)

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment

Cancer Medicine, Volume 15, Issue 1, January 2026.
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang, Binle Tian, Jingyi Zhou, Di Ma, Rongze Sun, Qi Li   +5 more
wiley   +1 more source

A directionally evolved genomic feature in BRSK2 harbors divergent alleles in neurocognitive disorders. [PDF]

Sci Rep
Ohadi M, Bayat H, Khamse S, Delbari A, Arabfard M.   +4 more
europepmc   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Advancing Gene Therapy for Phenylketonuria: From Precision Editing to Clinical Translation. [PDF]

Int J Mol Sci
Yu I, Jeong J.
europepmc   +1 more source

The 5′ Cap Epitranscriptome and Beyond: Natural and Engineered 5′ Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies

ChemMedChem, Volume 21, Issue 2, January 2026.
5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm, Melissa Pieper, Helena Schepers, Andrea Rentmeister   +3 more
wiley   +1 more source

Transcriptome mining reveals diversity and evolution of circulating and endogenous amphibian retroviruses. [PDF]

Retrovirology
Harding EF, Webster B, Sridhar T, Mercer LK, White PA.   +4 more
europepmc   +1 more source

Long non‐coding RNA lncAPAT promotes atherosclerotic plaque instability by targeting ribosomal protein L22

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
LncAPAT interacted with the promoter region of RPL22 to inhibit RPL22 transcriptional activity and increase the expression of MCP‐1, thereby contributing to plaque instability. Abstract Background Long non‐coding RNAs (lncRNAs) regulate macrophage inflammation and atherosclerotic plaque stability, but mechanisms need comprehensive investigations ...
Rongxia Li, Qiyue Zhang, Yu Chen, Shuting Wang, Shuang Han, Adalaiti Kamili, Yixuan Zhong, Shujun Yang, Weili Zhang   +8 more
wiley   +1 more source

Screening of CGG Trinucleotide Repeats Within <i>FMR1</i> Gene in Bangladeshi Children With Autism Spectrum Disorder: Exploring a Possible Link With Fragile X Syndrome. [PDF]

J Korean Acad Child Adolesc Psychiatry
Noman AA, Saba AA, Adiba M, Rahman M, Sayem M, Nabi AHMN, Yasmin T.   +6 more
europepmc   +1 more source

Lonicera caerulea Berry Polyphenols Regulate Cholesterol Metabolism in Rats With Type 2 Diabetes by Activating SIRT1 Expression in Macrophages and Reducing Foaming

Food Frontiers, Volume 7, Issue 1, January 2026.
1. Dietary LCBP supplementation in T2DM rats can improve abnormal cholesterol metabolism. 2. LCBP inhibits the formation of foam cells of macrophages of T2DM rats. 3. LCBP activated SIRT1 by enhanced the regulation of miR‐33/SREBP2 and ABCA1, but this effect was not dependent on SIRT1. 4.
Suwen Liu, Wenhong Jiang, Hanchen Li, Xuli Wang, Jiancheng Ma, Lina Dong   +5 more
wiley   +1 more source

Characterization of Novel Luteoviruses in Canadian Highbush Blueberries Using High-Throughput Sequencing. [PDF]

Viruses
Kannangara S, Gilewski A, Rodriguez Lopez J, de Villiers G, Ellis M, Ellis P, Gerbrandt E, Mattsson J.   +7 more
europepmc   +1 more source