Results 221 to 230 of about 34,778 (266)

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways

MedComm, Volume 7, Issue 1, January 2026.
Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho, Jeongmi Lee, Bo Youn Choi, Jin‐Ho Yun, Sukmin Han, Seung Hyun Baek, Jinsu Park, Yoonsuk Cho, Hark Kyun Kim, Eunae Kim, Leon F. Palomera, Jeein Lim, Yeji Jeon, Jeonghyeong Im, Ju‐Mi Hong, Tai Kyoung Kim, Sung Hyun Kim, Joung Han Yim, Dong‐Gyu Jo   +18 more
wiley   +1 more source

RNA chemistry and therapeutics. [PDF]

Nat Rev Drug Discov
Wang S, Weissman D, Dong Y.
europepmc   +1 more source

Breast Cancer: Molecular Pathogenesis, Targeted Therapy, Screening, and Prevention

MedComm, Volume 7, Issue 1, January 2026.
The review manuscript examines the molecular pathogenesis, screening, prevention advances, and evolving targeted therapies in breast cancer. It highlights the integration of AI and multiomics for precision prevention and personalized treatment, pointing toward future directions in equitable cancer care.
Huijun Lei, Jinzhen Fu, Wei Gu, Hongjin Qiao, Huixue Guo, Zijian Chen, San Ming Wang, Tianhui Chen   +7 more
wiley   +1 more source

Prolonged Survival with Dieting for Improved Autophagy. [PDF]

Noncoding RNA
Fukumoto A, Nakashima M, Matsuda S.
europepmc   +1 more source

A Novel Intronic Variant Causes Aberrant Splicing of PCDH15 in a Family With Usher Syndrome Type 1F

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
Minigene splicing assays elucidated the pathogenicity of a novel intronic c.3717+5G>A mutation in the PCDH15 gene, which was identified in a family affected by Usher syndrome type 1F. The results demonstrated that the c.3717+5G>A mutation can lead to exon 27 skipping and retention of 51 bp at the 5′ end of intron 27, resulting in truncated or abnormal ...
Qifan Ma, Chenyang Xu, Xueqin Xu, Yanbao Xiang   +3 more
wiley   +1 more source

Novel variants in ARID1B, SPSB1, and RAET1-AS shape genetic susceptibility and protection in systemic lupus erythematosus and lupus nephritis. [PDF]

J Transl Autoimmun
Chen HY, Liu FC, Chen HC, Liu TM, Yeh FC, Chang YT.   +5 more
europepmc   +1 more source

Tissue tropism and functional adaptation of the SARS-CoV-2 spike protein in a fatal case of COVID-19. [PDF]

J Virol
Johnson KEE, Stein S, Boateng RA, Jain S, Ramelli SC, Stantliff T, Curran S, Ramos-Benítez MJ, Platt AP, Banakis S, Wang W, Hewitt SM, Zerbe C, Holland SM, Kang EM, Singh M, de Wit E, Lauer WA, Rouchka EC, Smith M, Suthar MS, Chertow DS, Ghedin E.   +22 more
europepmc   +1 more source

Hammerhead Ribozymes: Structural Insights, Catalytic Mechanisms, and Cutting-Edge Applications in Synthetic Biology. [PDF]

Int J Mol Sci
Wang L, Liu Y, Xian X, Zhang H.
europepmc   +1 more source

Coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirus. [PDF]

Sci Rep
Łukaszuk E, Dziewulska D, Varsani A, Stenzel T.   +3 more
europepmc   +1 more source