Results 31 to 40 of about 34,778 (266)

Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. [PDF]

, 2017
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation.
Amaral, Maria Luisa, Benner, Christopher, Hargreaves, Diana C, Kelso, Timothy WR, Porter, Devin K, Shokhirev, Maxim N   +5 more
core   +1 more source

Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations.

RNA: A publication of the RNA Society, 2002
The Fragile X mental retardation gene (FMR1) contains a polymorphic trinucleotide CGG repeat in the 5' untranslated region (UTR) of the FMR1 messenger.
B. Primerano, F. Tassone, R. Hagerman, P. Hagerman, F. Amaldi, C. Bagni   +5 more
semanticscholar   +1 more source

Isolation and characterization of the full-length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni [PDF]

, 2005
Cytochrome p450s (cyp450s) are a family of structurally related proteins, with diverse functions, including steroid synthesis and breakdown of toxins. This paper reports the full-length sequence of a novel cyp450 gene, the first to be isolated from the ...
Altschul SF, Anne E Lockyer, Brown DJ, Catherine S Jones, Chang GWM, Chaty S, David Rollinson, Gough J, Leslie R Noble, Lockyer AE, Madera M, Nelson DR, Nelson DR, Omura T, Sambrook J, Snyder MJ, Snyder MJ, Teunissen Y   +17 more
core   +5 more sources

Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms [PDF]

, 2006
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal residues that are recognized directly by
Brower, Christopher S., Davydov, Ilia V., Hu, Rong-Gui, Kwon, Yong Tae, Sheng, Jun, Varshavsky, Alexander, Wang, Haiqing, Zhou, Jianmin   +7 more
core   +2 more sources

The Sequence Ontology: a tool for the unification of genome annotations [PDF]

, 2005
The Sequence Ontology ( SO) is a structured controlled vocabulary for the parts of a genomic annotation. SO provides a common set of terms and definitions that will facilitate the exchange, analysis and management of genomic data.
Ashburner, M., Durbin, R., Eilbeck, K., Lewis, S. E., Mungall, C. J., Stein, L. D., Yandell, M.   +6 more
core   +2 more sources

The miR-155-5p/FBXO11 axis inhibits the progression of gastric cancer via the mTOR pathway

Translational Cancer Research
Background Gastric cancer (GC) is a leading cause of cancer-related death. MicroRNAs (miRNAs or miRs) play a crucial role in the pathology of GC, including cell proliferation, invasion, and metastasis.
Tao Yuan, Haiyan Liu, Fangfang Li, Qingyue Meng, Yajuan Wang, Mei Yuan   +5 more
semanticscholar   +1 more source

Improving the Caenorhabditis elegans Genome Annotation Using Machine Learning [PDF]

, 2007
For modern biology, precise genome annotations are of prime importance, as they allow the accurate definition of genic regions. We employ state-of-the-art machine learning methods to assay and improve the accuracy of the genome annotation of the nematode
Bernhard Schölkopf, Gunnar Rätsch, Hanh Witte, Jagan Srinivasan, Klaus-R Müller, Ralf-J Sommer, Sören Sonnenburg, The Caenorhabditis elegans sequencing consortium, Uwe Ohler   +8 more
core   +6 more sources

Increased HLA-G Expression in Term Placenta of Women with a History of Recurrent Miscarriage Despite Their Genetic Predisposition to Decreased HLA-G Levels

International Journal of Molecular Sciences, 2019
Human leukocyte antigen (HLA)-G is an immune modulating molecule that is present on fetal extravillous trophoblasts at the fetal-maternal interface. Single nucleotide polymorphisms (SNPs) in the 3 prime untranslated region (3′UTR) of the HLA-G gene can ...
M. Craenmehr, I. Nederlof, Milo Cao, J. Drabbels, M. Spruyt-Gerritse, J. Anholts, H. Kapsenberg, Janine A Stegehuis, C. van der Keur, Esther Fasse, G. Haasnoot, M. P. van der Hoorn, F. Claas, S. Heidt, M. Eikmans   +14 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

VH-RELATED IDIOTOPES DETECTED BY SITE-DIRECTED MUTAGENESIS [PDF]

, 1992
The function of the CD4 cell surface protein as coreceptor on T helper lymphocytes and as receptor for HIV makes this glycoprotein a prime target for an immune intervention with mAb.
Cheng, Y. H., Rieber, Ernst Peter, Riethmüller, Gert, Weiss, Elisabeth H., Weissenhorn, Winfried   +4 more
core   +1 more source