Results 61 to 70 of about 18,606 (197)

Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts

Advanced Science, EarlyView.
This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu, Yu Zhou, Huimin Wang, Yaxi Wu, Rui Han, Shili Liu, Feng Jiang, Xiaojiao Guo, Meiling Yang   +8 more
wiley   +1 more source

Functional filter for whole genome sequence data identifies stress impact, non-coding, alternate polyadenylation site variants >5kb from coding DNA

medRxiv, 2023
S. Xiao, Z. Kai, Daniel Murphy, Dongyang Li, D. Patel, Adrianna M. Bielowka, M. Bernabeu-Herrero, Awatif Abdulmogith, A. Mumford, S. Westbury, M. Aldred, N. Vargesson, M. Caulfield, Genomics England, Research Consortium, C. Shovlin   +15 more
semanticscholar   +1 more source

m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An, Yuhao Wu, Jingzhe Han, Pingping Fang, Yi Bu, Guang Ji, Jinliang Deng, Xueqin Song   +7 more
wiley   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

N6‐methyladenosine‐regulated exosome biogenesis orchestrates an immunosuppressive pre‐metastatic niche in gastric cancer peritoneal metastasis

Cancer Communications, EarlyView.
Abstract Background Gastric cancer peritoneal metastasis is clinically challenging, given the limited treatment options and poor prognosis. The molecular mechanisms that precede gastric cancer peritoneal metastasis, known as the pre‐metastatic niche (PMN), and its relationship with N6‐methyladenosine (m6A) modification remain unclear.
Song Li, Jianyuan Zhou, Shuang Wang, Qian Yang, Shulun Nie, Chunwang Ji, Xue Zhang, Shuhan Li, Xuanyu Zhou, Jiahui Chu, Xuehui Wu, Jianqiao Jiao, Ruitao Xu, Qian Xu, Miao Huang, Qiushi Wang, Liliang Dou, Qinqin Hu, Fan Jiang, Xin Dai, Zhaodi Nan, Xinyu Song, Di Zhang, Lian Liu   +23 more
wiley   +1 more source

Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47

Cancer Communications, EarlyView.
Abstract Background Only a few bladder cancer patients benefit from anti‐programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immune evasion. CD47 is a highly glycosylated protein, however, the mechanisms governing CD47 glycosylation and its potential ...
Jie Zhang, Chen Zhang, Ruichen Zang, Weiwu Chen, Yining Guo, Haofei Jiang, Jing Le, Kunyu Wang, Haobo Fan, Xudong Wang, Sisi Mo, Peng Gao, Wenhao Guo, Xinrong Jiang, Fengbin Gao, Junming Jiang, Juyan Zheng, Yuxing Chen, Yicheng Chen, Yanlan Yu, Guoqing Ding   +20 more
wiley   +1 more source

Coordinated gene expression within sustained STAT3‐associated chromatin conformations contributes to hepatocellular carcinoma progression

Cancer Communications, EarlyView.
Abstract Background Phosphorylated signal transducer and activator of transcription 3 (p‐STAT3) has emerged as a critical modulator of hepatocellular carcinoma (HCC) progression. However, its role in three‐dimensional (3D) chromatin conformation and the expression of genes linked to HCC aggressiveness remains largely unexplored.
Sunyoung Jang, Sumin Yoon, Hyeokjun Yang, Nayun Choi, Su‐Hyang Han, Lark Kyun Kim, Hyoung‐Pyo Kim, Jong Hoon Park, Daeyoup Lee, Kyung Hyun Yoo   +9 more
wiley   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

Development of node architecture and emergence of molecular organizer characteristics in the pig embryo

Developmental Dynamics, EarlyView.
Abstract Background The avian node is the equivalent of the amphibian Spemann's organizer, as indicated by its ability to induce a secondary axis, cellular contribution, and gene expression, whereas the node of the mouse, which displays limited inductive capacities, was suggested to be a part of spatially distributed signaling.
Braah Harmoush, Christoph Viebahn, Nikoloz Tsikolia   +2 more
wiley   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source