Results 41 to 50 of about 1,468,325 (269)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Threshold and Deadline Effect in Crowdfunding

open access: yesProcedia Computer Science, 2019
Abstract The deadline effect and threshold effect are common in product development and group buying. We consider these two effects also exist in crowdfunding, affecting the crowdfunding performance in the future. We conduct an empirical study using a dataset from Kickstarter.com to examine these two effects and their interactive relationship on the ...
Yan Song, Xin Tian 0003, Chunlin Luo
openaire   +1 more source

Effects of threshold resummation [PDF]

open access: yesPhysics Letters B, 1999
12 pages, 2 ...
Lai, Hung-Liang, Li, Hsiang-nan
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The Threshold and Lag Effects of Temperature on Pine Wilt Disease Show Significant Spatial Heterogeneity

open access: yesInsects
Pine wilt disease (PWD) is an economically important disease. With the increasing temperature caused by climate change, there is a concern that it may expand to regions currently at low risk, cause more serious ecological harm and economic losses in ...
Ruicong Zhang   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Threshold and mediating effects of new urbanization on residential building carbon emissions: evidence from Chinese pilot cities

open access: yesFrontiers in Public Health
IntroductionIn the context of China’s new urbanization strategy and its “dual-carbon” goals, understanding the impact of urban transformation on carbon emissions in the residential sector is crucial.
Yongkun Wang, Zhuo Tong, Yunhui Zhang
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Phase-specific mortality risk of serum lactate thresholds in very low birth weight infants with late-onset sepsis: a retrospective cohort study

open access: yesFrontiers in Medicine
BackgroundLate-onset sepsis (LOS) in very low birth weight (VLBW) infants confers substantial mortality risk. While lactate monitoring is standard, validated prognostic thresholds for mortality remain unestablished in this population.MethodsThis ...
Yu Lun   +4 more
doaj   +1 more source

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