Results 181 to 190 of about 3,798,889 (297)

Liability threshold model-based disease risk prediction based on electronic health record phenotypes. [PDF]

Nat Genet
Lee CH, Khan A, Wang C, Weng C, Buxbaum JD, Kiryluk K, Ionita-Laza I.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Retraction: Corporate social responsibility stimulus on environmental problems: Spatial threshold model analysis. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

A distress-continuum, disorder-threshold model of depression: a mixed-methods, latent class analysis study of slum-dwelling young men in Bangladesh. [PDF]

BMC Psychiatry, 2021
Wahid SS, Sandberg J, Sarker M, Arafat ASME, Apu AR, Rabbani A, Colón-Ramos U, Kohrt BA.   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Combining greedy and evolutionary algorithms to maximize influence in networks under deterministic linear threshold model. [PDF]

PLoS One
Andreev A, Kochemazov S, Semenov A.
europepmc   +1 more source

A network-based microfoundation of Granovetter's threshold model for social tipping. [PDF]

Sci Rep, 2020
Wiedermann M, Smith EK, Heitzig J, Donges JF.   +3 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Questioning the Linear No-Threshold Model (LNT): Lessons From Hiroshima/Nagasaki and Fukushima. [PDF]

Dose Response
Sutou S.
europepmc   +1 more source

A linear threshold model for optimal stopping behavior. [PDF]

Proc Natl Acad Sci U S A, 2020
Baumann C, Singmann H, Gershman SJ, von Helversen B.   +3 more
europepmc   +1 more source