Results 61 to 70 of about 121,764 (250)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Non-universal transmission phase behaviour of a large quantum dot

, 2017
The electron wave function experiences a phase modification at coherent transmission through a quantum dot. This transmission phase undergoes a characteristic shift of $\pi$ when scanning through a Coulomb-blockade resonance.
Bäuerle, C., Edlbauer, H., Ludwig, A., Meunier, T., Roussely, G., Takada, S., Tarucha, S., Wieck, A. D., Yamamoto, M.   +8 more
core   +4 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A variable threshold ring signature scheme for privacy protection in smart city blockchain applications

Discover Computing
In smart city deployments, blockchain offers decentralized control over services and data, yet it also introduces stringent privacy and scalability challenges.
Guo Hongzhi, Qin Haowen
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Creating and probing long-range order in atomic clouds

, 2005
Ultracold atoms interacting with the optical modes of a high-Q optical ring cavity can synchronize their motion. The collective behavior makes the system interesting for quantum computing applications. This paper is devoted to the study of the collective
Alt, Berman, Birkl, Black, Bonifacio, Bonifacio, Bonifacio, Brown, Brown, Burke Jr., Chow, Cirac, Courteille, Courtois, Dalibard, DeMille, Domokos, Elsässer, Gangl, Gangl, Greiner, Grimm, Guo, Haken, Hemmer, Hemmerich, Javaloyes, Javaloyes, Kozuma, Kruse, Kruse, Kruse, Kuramoto, Lippi, Mandel, Meacher, Micheli, Moore, Mosk, Nagorny, Nicolis, Nägerl, Perrin, Piovella, Piovella, Piovella, Raithel, Robb, Slama, Slama, Slama, Strogatz, Strogatz, von Cube, von Cube, Vuletic, Weidemüller, Weidemüller, Wiggins   +58 more
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

ATP‐Dependent Thermo‐Ring Basis for the Heat Unfolding of the First Nucleotide‐Binding Domain Isolated From Human CFTR

Natural Sciences
The creative concept of “thermo‐rings” has recently been developed to characterize the tightened noncovalent network of interactions that drive the tertiary folding of a protein.
Guangyu Wang
doaj   +1 more source