Results 31 to 40 of about 1,268,925 (240)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Anonymous Cluster-Based MANETs with Threshold Signature

International Journal of Distributed Sensor Networks, 2013
Security supports are a significant factor in the design of security system in ad hoc networks. It is particularly important to protect the identities of individual nodes to avoid personal privacy concerns. In this paper, we propose a security system for
YoHan Park, YoungHo Park, SangJae Moon
doaj   +1 more source

An Algorithm of (n, t)-Threshold Proxy Signature with an Arbitrator

Моделирование и анализ информационных систем, 2013
The paper presents an (n, t)-threshold proxy signature scheme with an Arbitrator which enables an original signer to delegate the signature authority to sign a message on behalf of the original signer to proxy group P of n members.
E. A. Tolyupa
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Threshold ring signature: generic construction and logarithmic size instantiation

Cybersecurity
A ring signature is a variant of normal digital signature and protects the privacy of a specific signer in the sense that a ring signature can be verified, but the signer’s identity can only be traced to a limited set. The concept was further enhanced to
Huizhuo Wang, Yang Tao, Rui Zhang
doaj   +1 more source

Multi-threshold signature [PDF]

, 2008
The work presents a new signature scheme, called the multi-threshold signature, which generalizes the concept of multisignature and threshold signature.
Pomykała, J., Nakielski, B., Pomykała, J. A.   +2 more
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Blockchain-Based Information Security Protection Mechanism for the Traceability of Intellectual Property Transactions

Sensors
Traditional intellectual property transaction traceability has problems such as information asymmetry, traceability information storage methods relying on centralized databases, and easy tampering of transaction information, etc.
Zheng Wang, Wenlong Feng, Mengxing Huang, Siling Feng, Shilong Mo, Yunhong Li   +5 more
doaj   +1 more source