Results 171 to 180 of about 123,159 (318)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A Robust Multivariate Thresholding Function for Sparse and Biomedical Signal Reconstruction. [PDF]

Sensors (Basel)
Ullah H, Gaire S, Graves CA.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The impact of tissue detection on diagnostic artificial intelligence algorithms in prostate digital pathology. [PDF]

Sci Rep
Boman SE, Mulliqi N, Blilie A, Ji X, Szolnoky K, Gudlaugsson E, Janssen EAM, Kjosavik SR, Asenjo J, Gambacorta M, Libretti P, Braun M, Kordek R, Łowicki R, Hotakainen K, Väre P, Pedersen BG, Sørensen KD, Ulhøi BP, Egevad L, Kartasalo K.   +20 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Stochastic Approximator of Motor Threshold (SAMT) for Transcranial Magnetic Stimulation: Online Software and Its Performance in Clinical Studies. [PDF]

Transcranial Magn Stimul
Wang B, Shah VU, Koponen LM, Neacsiu AD, Daskalakis ZJ, Fitzgerald PB, Appelbaum LG, Choi JY, Gerlus N, Li Y, Hadas I, Sun Y, Poorganji M, Daniels H, Rodriguez K, Gotsis ES, Bailey NW, Raveendran J, Brinley SK, Gallo AT, Goetz SM, Peterchev AV.   +21 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Unsupervised Wildfire Detection Using Multispectral MTG-FCI Data: A Feasibility Study. [PDF]

J Imaging
Mercatini A, Tartaglione N.
europepmc   +1 more source

Moment-Preserving Thresholding Using Gamma Distribution

, 2010
Image thresholding is an essential function in image processing. It is used to segment images in a simple, yet affective approach. One of the most popularthresholding techniques is moment-preserving thresholding proposed by Tsai in 1985.
Ali El-Zaart, Arwa Al-Hussain
core