Results 71 to 80 of about 662,743 (219)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
EnergiesThis article presents the evaluation of the performance of the distance relay (ANSI function 21) when integrating Distributed Energy Resources (DERs) in a Local Distribution System (LDS).
David R. Garibello-Narváez +2 more
doaj +1 more source
Are We Entering an Era of Concatenated Global Crises?
Ecology and Society, 2011 An increase in the frequency and intensity of environmental crises associated with accelerating human-induced global change is of substantial concern to policy makers.
Duan Biggs +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
AgronomyReliable soil critical values (SCVs) for micronutrients are essential for accurate fertilizer recommendations. This study established crop-specific SCVs for boron (B), copper (Cu), iron (Fe), manganese (Mn), and zinc (Zn) extracted with Mehlich-3 under ...
Jolanta Korzeniowska +2 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Waist-to-Height Ratio Cut offs for Metabolic Syndrome Screening in Adults: A Structured Narrative Review of Population Differences and Predisposing Factors [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Metabolic Syndrome (MetS) is a growing challenge with serious health consequences. The Waist-to-Height Ratio (WHtR) is a simple and cost-effective screening tool for MetS; however, its thresholds vary across different populations.
Amirhossein Soleymani +3 more
doaj