Results 71 to 80 of about 3,107 (209)

A CASE REPORT ON GLANZMANN'S THROMBASTHENIA

, 2017
Glanzmann’s thrombasthenia (GT) is a rare autosomal recessive disorder in which the platelet glycoprotein IIb/IIIa (GP IIb/IIIa) complex is either deficient or, dysfunctional. The incidence is about 1 in 1,000,000.
Annamol Joseph*, Rinto Paul Raju, Alen Joe Francy, L.Britto Duraisingh, Haja Sherief S, T Sivakumar.
core   +1 more source

Glanzmann Thrombasthenia - Challenging Gastrointestinal Bleeding Without Definitive Management Guidelines

, 2023
Introduction: Gastrointestinal bleeding is a life-threatening complication of Glanzmann thrombasthenia (GT), an inherited platelet disorder caused by mutations of the platelet-fibrinogen receptor integrin αIIbβ3.
Farqooq, Umer, Boustany, Antoine, Onwuzo, Somtochukwu, Palagiri, Jennifer, Thomas, Alexander, Gharaibeh, Eyad Z, El Alayli, Abdallah, Chaudhary, Ammad   +7 more
core   +1 more source

Mon‐Pu (Glochidion perakense Hook.f.) as a Promising Novel Natural Source of Antithrombotic and Antioxidant Benefits

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Current evidence suggests that regular consumption of food‐functioned fruits and vegetables could reduce the risk of thrombosis. While some indigenous vegetables from Southern Thailand have been reported to exhibit anticoagulant and antiplatelet activities, their fibrinolytic and thrombolytic properties remain unexplored.
Surachai Techaoei, Muhammad Junaid, Warachate Khobjai, Suriyan Sukati, Anjali Chauhan   +4 more
wiley   +1 more source

Identification of Key Genes and Pathways Associated With Gender Differences in Pulmonary Arterial Hypertension Based on Bioinformatic Approaches

BioMed Research International, Volume 2026, Issue 1, 2026.
Pulmonary arterial hypertension (PAH) is a complex disease with multiple contributing factors. Epidemiological data showed that women are more susceptible to PAH, but they tend to have better right ventricular (RV) function and prognosis compared to men. The mechanisms behind these gender differences are not well understood.
Mohammad Panahi, Reyhaneh Kalhor, Mohammad-Hossein Mokhtarian, Fatemeh Javaheri Tehrani, Zinat Shams, Hourieh Kalhor, Hannah Wesley   +6 more
wiley   +1 more source

Allogeneic hematopoietic cell transplantation in an adult patient with Glanzmann thrombasthenia

Clinical Case Reports, 2017
Key Clinical Message Glanzmann thrombasthenia is a rare bleeding disorder that can present life‐threatening bleeding. Our patients develop antiplatelet antibodies that become refractory to any pharmacological treatment. Allogeneic hematopoietic stem‐cell
Ana R. Cid, Pau Montesinos, Isabel Sánchez‐Guiu, Saturnino Haya, Jose I. Lorenzo, Jaime Sanz, Federico Moscardo, Nieves Puig, Dolores Planelles, Santiago Bonanad, Guillermo F. Sanz, Vicente Vicente, Consuelo González‐Manchón, María L. Lozano, José Rivera, Miguel A. Sanz   +15 more
doaj   +1 more source

Novel Mutation in ITGB3: A Case Report of Glanzmann Thrombasthenia-like Syndrome Associated with Macrothrombocytopenia

Journal of Applied Hematology
Congenital thrombocytopenias are a diverse range of diseases. Of them, Glanzmann thrombasthenia is an autosomal recessive platelet aggregation disorder due to defect in the alpha IIb/beta3 integrins, coded by the ITGA2B and ITGB3 genes.
Abdulrhman Ibrahim Alathaibi, Muhammad Matloob Alam, Mohammed Kamal, Mohamed Refai, Faisal Alosaimi, Omar Allehyani, Nojood Althubaity   +6 more
doaj   +1 more source

Acquired Platelet Dysfunction Secondary to Myelodysplastic Neoplasm: Successful Resolution With Neoplasm‐Directed Therapy

Case Reports in Hematology, Volume 2026, Issue 1, 2026.
Acquired platelet dysfunction has been reported as a complication of hematologic malignancies. Diagnosis and management of platelet dysfunction with a concomitant myeloid disorder can be challenging, and there is a need for real‐world experience reports to help clinicians recognize these entities and manage them accordingly. Herein, we report a case of
Amy Hockman, Georgio Medawar, Lilong Guo, Elizabeth Rinker, Praneeth Baratam, Kalyani Sen   +5 more
wiley   +1 more source

Co‐inheritance of ITGA2B and TUBB1 variants in a family reveals distinct genetic contributions to platelet dysfunction

British Journal of Haematology, Volume 208, Issue 6, Page 2298-2303, June 2026.
Perla Bandini, Nina Borràs, Laura Martin‐Fernandez, Nuria Fernández‐Mosteirín, Maria Reyes Aguinaco, Olga Benítez, Natàlia Comes, Lorena Ramírez, Noemí González, Carina Lera, Carme Altisent, Francisco Vidal, Irene Corrales   +12 more
wiley   +1 more source

The use of recombinant FVIIa in a patient with Glanzmann thrombasthenia with uncontrolled bleeding after tonsillectomy

, 2009
Glanzmann's thrombasthenia is an inherited platelet function disorder caused by quantitative or qualitative defects of the platelet membrane glycoprotein NUMB complex.
ZAMAN, Dilek, AKSOY, Ayse, ERDURAN, EROL
core   +1 more source

Perioperative management of a patient with glanzmann's thrombasthenia for mitral valve repair under cardiopulmonary bypass

Annals of Cardiac Anaesthesia, 2017
A 30-year-old male patient presented with Glanzmann's thrombasthenia and mitral valve prolapse. He was in acute decompensated congestive heart failure due to severe mitral and tricuspid regurgitation.
Parimala Prasanna Simha, Prasanna Simha Mohan Rao, Deepak Arakalgud, Rakesh Rajashekharappa, Manjunath Narasimhaih   +4 more
doaj   +1 more source