Results 211 to 220 of about 432,090 (383)

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, EarlyView.
What's New? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

Efficacy and safety of fruquintinib combined with albumin‐bound paclitaxel as second‐line therapy for advanced gastric cancer following failure of PD‐1 inhibitor‐containing treatment (TACTIC GC‐01): A phase II single‐arm study

International Journal of Cancer, EarlyView.
What's New? Anti‐angiogenic drugs have shown promising efficacy as a second‐line treatment for advanced gastric cancer. However, it remains unclear how alterations in the tumor microenvironment following first‐line immunotherapy may impact tumor angiogenesis and influence subsequent therapeutic outcomes. This single‐arm study prospectively explored the
Xiaoting Ma, Kai Ou, Xiu Liu, Biyang Cao, Wenwei Yang, Jingyu Lu, Letian Zhang, Qi Wang, Lizhen Gao, Zhichao Jiang, Yongkun Sun, Lin Yang   +11 more
wiley   +1 more source

Prenatal vitamin D levels and postpartum hemorrhage in a rural Alaska cohort

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To examine the relationship between prenatal vitamin D serum levels and postpartum bleeding. Methods We conducted a retrospective electronic health record cohort study of pregnant Alaska Native and American Indian (ANAI) people in southwestern Alaska who had at least one prenatal vitamin D level measurement recorded and had a vaginal
Reinou S. Groen, Julie A. Beans, Gretchen Day, Lauryl Torkelson, Anjali Madeira, David Compton, Joseph Klejka, Jennifer Shaw   +7 more
wiley   +1 more source

Evidence that platelet-derived microvesicles may transfer platelet-specific immunoreactive antigens to the surface of endothelial cells and CD34+ hematopoietic stem/ progenitor cells--implication for the pathogenesis of immune thrombocytopenias.

, 2007
Marcin Majka, Jacek Kijowski, Ewa Lesko, Jolanta Goźdizk, B Zupańska, Mariusz Z. Ratajczak   +5 more
openalex   +2 more sources

Association of re‐amniotomy in prelabor rupture of membranes at term and increased risk of cesarean delivery

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To determine delivery outcomes in women diagnosed with prelabor rupture of membranes (PROM) who required re‐amniotomy. Methods This retrospective cohort study included 24 966 women with PROM at a single university‐affiliated tertiary medical center (2011–2023).
Roza Berkovitz‐Shperling, Roni Berin, Daniel Gabbai, Yariv Yogev, Shai Ram   +4 more
wiley   +1 more source

Viper (Agkistrodon halys blomhoffii "Mamushi") Bite with Remarkable Thrombocytopenia

, 2005
Motoki Fujita, Susumu Yamashita, Yoshikatsu Kawamura, Ryosuke Tsuruta, Shunji Kasaoka, Kiyoshi Okabayashi, Tsuyoshi Maekawa   +6 more
openalex   +2 more sources

Cytokine-Mediated Disruption of Lymphocyte Trafficking, Hemopoiesis, and Induction of Lymphopenia, Anemia, and Thrombocytopenia in Anti-CD137-Treated Mice [PDF]

, 2007
Liguo Niu, Simona Strahotin, Becker Hewes, Benyue Zhang, Yuanyuan Zhang, David R. Archer, H. Trent Spencer, Dirck L. Dillehay, Byoung S. Kwon, Lieping Chen, Anthony T. Vella, Robert S. Mittler   +11 more
openalex   +1 more source

Hemostatic abnormalities at the time of fetal death: A retrospective study evaluating the prevalence and relevance of targeted testing

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To assess the prevalence of hemostasis abnormalities at the time of fetal death diagnosis. Methods This retrospective single‐center study included all fetal deaths between 22 and 42 weeks from July 2017 to December 2023, excluding multiple pregnancies, patients on anticoagulant therapy, and those with known pre‐existing coagulation ...
Chloé Lieng, Catherine Fischer, Aude Girault   +2 more
wiley   +1 more source

The impact of platelet transfusion characteristics on posttransfusion platelet increments and clinical bleeding in patients with hypoproliferative thrombocytopenia [PDF]

, 2012
Darrell J. Triulzi, Susan F. Assmann, Ronald G. Strauss, Paul M. Ness, John R. Hess, Richard M. Kaufman, Suzanne Granger, Sherrill J. Slichter   +7 more
openalex   +1 more source

First Report of Eltrombopag Induced Severe Autoimmune Hemolytic Anemia in the Management of Waldenström Macroglobulinemia-associated Autoimmune Thrombocytopenia [PDF]

, 2021
Yingying Shen, Hangping Ge, Baodong Ye, Zhiyin Zheng, Keding Shao, Yuhong Zhou, Yiping Shen, Dijiong Wu   +7 more
openalex   +1 more source