Results 121 to 130 of about 312,196 (386)

The Khorana score for prediction of venous thromboembolism in cancer patients: a systematic review and meta-analysis

Haematologica, 2019
We aimed to evaluate the performance of the Khorana score in predicting venous thromboembolic events in ambulatory cancer patients. Embase and MEDLINE were searched from January 2008 to June 2018 for studies which evaluated the Khorana score. Two authors
F. Mulder, M. Candeloro, P. Kamphuisen, M. Di Nisio, P. Bossuyt, N. Guman, K. Smit, H. Büller, N. van Es   +8 more
semanticscholar   +1 more source

Association between obesity and venous thromboembolism

Medicine and Pharmacy Reports, 2020
Background and aims Obesity is associated with numerous pathological conditions, including venous thromboembolism (VTE). VTE is a multifactorial disease; more than half of the hospitalized patients are at risk for VTE.
C. Hoţoleanu
semanticscholar   +1 more source

Quantitative Model‐Informed Dose Selection for a Milvexian Phase III Study in Patients With Atrial Fibrillation

Clinical Pharmacology &Therapeutics, EarlyView.
Milvexian, an activated factor XI inhibitor, is being evaluated in the LIBREXIA phase III program for the prevention of thrombotic events, including in patients with atrial fibrillation (LIBREXIA AF). To guide the selection of a phase III dose regimen for LIBREXIA AF, two main approaches were used: (1) population pharmacokinetics and exposure–response ...
Wangda Zhou, Emily Bozenhardt, Gregory E. Alexander, Matthew L. Zierhut, Samira Merali, Antoinette Ajavon‐Hartmann, Peter Zannikos, Hyunmoon Back, EunYoung Suh, Navin Goyal, Mahesh N. Samtani, Alexei N. Plotnikov, Chandni Valiathan   +12 more
wiley   +1 more source

Catheter-Directed Thrombolysis for Submassive Pulmonary Embolism in the Third Trimester of Pregnancy

JACC: Case Reports, 2020
A 37-year-old woman presented with chest pain and shortness of breath in the third trimester of pregnancy. Diagnostic imaging demonstrated a saddle pulmonary embolism, severe impairment of right ventricular function, and an extensive deep venous thrombus.
Amanda J. Compadre, MD, Maureen Kohi, MD, R. Peter Lokken, MD, MPH, Sarah Blissett, MD, Ian S. Harris, MD, Jennifer Lucero, MD, Melissa G. Rosenstein, MD, MAS, Nasim C. Sobhani, MD   +7 more
doaj   +1 more source

Presyncope Is Associated with Intensive Care Unit Admission in Emergency Department Patients with Acute Pulmonary Embolism [PDF]

, 2020
Introduction: Syncope is common among emergency department (ED) patients with acute pulmonary embolism (PE) and indicates a higher acuity and worse prognosis than in patients without syncope.
Abraham, Ashley S., Bahl, Disha, Clague, Victoria A., Cotton, Dale M., Engelhart, Darcy C., Huang, Jie, Krauss, William C., Mark, Dustin G., Othieno, Alisha A., Reed, Mary E., Swanson, William P., Vinson, David R.   +11 more
core  

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Can Routine Investigation for Occult Pulmonary Embolism Be Justified in Patients with Deep Vein Thrombosis?

Vascular Specialist International
Purpose: This study aims to investigate whether routine screening for silent pulmonary embolism (PE) can be justified in patients with deep vein thrombosis (DVT).
Dimitrios A. Chatzelas, Apostolos G. Pitoulias, Vangelis Bontinis, Theodosia N. Zampaka, Georgios V. Tsamourlidis, Alkis Bontinis, Anastasios G. Potouridis, Maria D. Tachtsi, Georgios A. Pitoulias   +8 more
doaj   +1 more source

Frequency of Accidental and Symptomatic Thrombo-embolic Events in Patients with Gastrointestinal Cancer

پزشکی بالینی ابن سینا, 2022
Background and Objective: One of the complications that can cause significant death and disability in cancer patients is thromboembolic events. Since gastrointestinal cancers are among the most common cancers in the world and Iran, and there is little ...
Erfan Rajabi, Sohrab Kolivand, Azar Pirdehghan   +2 more
doaj  

Significant correlation of angiotensin converting enzyme and glycoprotein IIIa genes polymorphisms with unexplained recurrent pregnancy loss in north of Iran [PDF]

, 2016
Background: Spontaneous abortion is considered as the most complex problem during pregnancy. Thrombophilia is resumed as a cause of recurrent pregnancy loss (RPL). Glycoprotein IIIa (GPIIIa) gene is involved in thrombosis and abortion.
Farazmandfar, T., Fazelnia, S., Hashemi-Soteh, S.M.B.   +2 more
core   +1 more source

Comparison between different D‐Dimer cutoff values to assess the individual risk of recurrent venous thromboembolism: analysis of results obtained in the DULCIS study

International Journal of Laboratory Hematology, 2016
D‐dimer assay, generally evaluated according to cutoff points calibrated for VTE exclusion, is used to estimate the individual risk of recurrence after a first idiopathic event of venous thromboembolism (VTE).
G. Palareti, C. Legnani, B. Cosmi, E. Antonucci, N. Erba, D. Poli, S. Testa, A. Tosetto, V. De Micheli, A. Ghirarduzzi, M. R. Veropalumbo, Ugolotti Maria Chiara, D. Prisco, O. Paoletti, A. Falanga, S. Luigi, M. Donadini, Elena Rancan, R. Quintavalla, P. Ferrini, R. Santoro, F. Orlandini, R. Benedetti, M. Cattaneo, F. Lussana, Elena Bertinato, R. Cappelli, A. Pizzini, Lucia Angeloni, Armando D'angelo, L. Crippa, Roberta Bortolotti, M. Vandelli   +32 more
semanticscholar   +1 more source