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Thrombotic Thrombocytopenic Purpura
Pediatric Emergency Care, 2011In 1924, Dr Eli Moschcowitz described a 16-year-old adolescent girl with abrupt onset of petechiae, hemolytic anemia, followed by paralysis, coma, and death. Autopsy showed widespread hyaline thrombi in the terminal arterioles and capillaries of various organs. The syndrome described by Moschowitz is now known as thrombotic thrombocytopenic purpura.
Alex Koyfman +2 more
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Thrombotic thrombocytopenic purpura
Blood Coagulation & Fibrinolysis, 1992Thrombotic thrombocytopenic purpura is an uncommon disorder, but it continues to be of considerable interest. The disease mechanisms are unclear and the aetiology is unknown. Perhaps most enigmatic of all, the mode of action of plasma therapy, which successfully induces remission in about two-thirds of cases, is wholly inexplicable. There are currently
Theodore E. Warkentin +4 more
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Thrombotic thrombocytopenic purpura
Disease-a-Month, 2014Moschowitz first described thrombotic thrombocytopenic purpura (TTP) in 1925 in a 16-yearold female who presented with fever, petechiae, and a microangiopathic hemolytic anemia. Autopsy examination at the time revealed hyaline thrombi in the vascular beds of many organs. By 1947, several more cases were described and Singer suggested the term TTP.
Rami Y. Haddad +3 more
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Thrombotic Thrombocytopenic Purpura
New England Journal of Medicine, 2019Thrombotic Thrombocytopenic Purpura A 35-year-old man presented with a 2-day history of abdominal pain and headache. A peripheral-blood smear showed numerous schistocytes, and a diagnosis of thrombotic thrombocytopenic purpura was made.
Shruti Bhandari, Rohit Kumar
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Thrombotic thrombocytopenic purpura
The American Journal of Medicine, 1952Abstract 1.1. The clinical and pathologic observations of two cases of thrombotic thrombocytopenic purpura are presented. 2.2. This condition is characterized by the clinical triad of (1) hemolytic anemia; (2) thrombocytopenic purpura and (3) mental and neurologic abnormalities which may be bizarre or transient.
Benjamin R. Gendel +2 more
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Thrombotic Thrombocytopenic Purpura
Archives of Internal Medicine, 1984Freda Gardner, MD, Senior Assistant Resident, The Jewish Hospital of St Louis: A 42-year-old woman was in good health until four weeks prior to her admission, when she noted that minor trauma caused large ecchymotic lesions. One week prior to admission, she experienced the sudden onset of dysarthria, weakness and paresthesias of her right arm, light ...
Lorence A. Gutterman +1 more
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An update on pathogenesis and diagnosis of thrombotic thrombocytopenic purpura
Expert Review of Hematology, 2019Introduction: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumption thrombocytopenia, and organ injury. TTP pathophysiology is based on a severe
B. Joly, P. Coppo, A. Veyradier
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Thrombotic Thrombocytopenic Purpura
JAMA: The Journal of the American Medical Association, 1991CASE PRESENTATION —Charles T. Bingham III, MD A 27-YEAR-OLD man was transferred to The Johns Hopkins Hospital for evaluation of delirium. Five days prior to admission he had presented to another hospital with hematemesis and syncope. Esophagogastroduodenoscopy revealed the presence of a 0.5-cm gastric ulcer.
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Thrombotic thrombocytopenic purpura
The Journal of Maternal-Fetal & Neonatal Medicine, 2012A 34-year old primipara was admitted to hospital with dichorionic-diamniotic twins in 26+3 weeks of gestation. In suspicion of HELLP-syndrome, caesarean section was performed at 27+4 weeks of gestation, because of platelet count was reduced to 44000/µl. A re-laparotomy had to be performed because of intra-abdominal bleedings.
Anne-Sybil Gast +3 more
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THROMBOTIC THROMBOCYTOPENIC PURPURA
Medical Journal of Australia, 1957Abstract 1.1. Three additional cases of thrombotic thrombocytopenic purpura are reported. 2.2. The possibility of diagnosis of this disorder by biopsy of a lymph node selected at random is confirmed. 3.3. Evidence is presented that platelets and megakaryocytes which have passed through the pulmonary circulation are incorporated in the thrombotic ...
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