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Mechanistic insight into multiple antibody binding to ADAMTS13 in immune thrombotic thrombocytopenic purpura. [PDF]

Res Pract Thromb Haemost
Halkidis K, Meng C, Pillai VG, Shay M, Liu S, Zheng XL.   +5 more
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Thrombotic microangiopathy, hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: Rare manifestations of Russell’s viper (Daboia russelii) envenoming in Sri Lanka

, 2021
Background: Russell’s viper (Daboia russelii) of Family Viperidae is a highly venomous snake in Sri Lanka and is responsible for the most snakebite deaths. It commonly causes coagulopathy and neuroparalysis. Thrombotic microangiopathy (TMA) including the
R. Rathnayaka, P. Ranathunga, S. Kularatne   +2 more
semanticscholar   +1 more source

Thrombotic Thrombocytopenic Purpura [PDF]

Annual Review of Medicine, 1988
Platelet thrombus formation in small vessels is triggered by certain stimuli, including vascular injury, primary platelet agglutination, or both. The formation and dissolution of platelet thrombi is modulated by proteolysis, plasma factors, PGI2 synthesis and stability, and immune mechanisms.
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Incidence, diagnosis, and outcome of immune‐mediated thrombotic thrombocytopenic purpura: A nationwide survey by the Spanish registry of thrombotic thrombocytopenic purpura

Journal of clinical apheresis, 2021
Immune‐mediated thrombotic thrombocytopenic purpura (iTTP) is a rare disease characterized by the presence of anti‐ADAMTS13 autoantibodies. Achieving accurate information on incidence and customary disease management is important to provide appropriate ...
C. Pascual-Izquierdo, J. del Río-Garma, J. de la Rubia, A. Viejo, E. Mingot, J. Cid, X. Solanich, Jesús Fernández-Sojo, J. Martín-Sánchez, L. Hernández, J. Garcia-Gala, N. Alonso, Victoria González, Ana Oliva, I. Gómez-Seguí, R. Goterris, L. Guerra, F. García-Candel, M. Fernández-Docampo, M. Antelo, Ángel Salgado-Barreira, R. Salinas   +21 more
semanticscholar   +1 more source

Thrombotic Thrombocytopenic Purpura [PDF]

Thrombosis and Haemostasis, 1995
Recent studies indicate that CRTTP patients have excessive shear stress-induced platelet aggregation that is associated with the presence of ULvWF multimers in their plasma and increased vWF-binding to their platelets by flow cytometry. In these CRTTP patients, relapses, excessive shear-aggregation and the presence in their plasma of ULvWF forms are ...
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Thrombotic Thrombocytopenic Purpura

Pediatric Emergency Care, 2011
In 1924, Dr Eli Moschcowitz described a 16-year-old adolescent girl with abrupt onset of petechiae, hemolytic anemia, followed by paralysis, coma, and death. Autopsy showed widespread hyaline thrombi in the terminal arterioles and capillaries of various organs. The syndrome described by Moschowitz is now known as thrombotic thrombocytopenic purpura.
Alex Koyfman, Vincent W. Chiang, Elizabeth Brém   +2 more
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Thrombotic thrombocytopenic purpura

Blood Coagulation & Fibrinolysis, 1992
Thrombotic thrombocytopenic purpura is an uncommon disorder, but it continues to be of considerable interest. The disease mechanisms are unclear and the aetiology is unknown. Perhaps most enigmatic of all, the mode of action of plasma therapy, which successfully induces remission in about two-thirds of cases, is wholly inexplicable. There are currently
Theodore E. Warkentin, William G. Murphy, Jane C. Moore, Catherine P.M. Hayward, John G. Kelton   +4 more
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Diagnostic accuracy of the PLASMIC score in patients with suspected thrombotic thrombocytopenic purpura: A systematic review and meta‐analysis

Transfusion, 2020
The PLASMIC score was developed to identify patients with thrombotic microangiopathy who are most likely to have immune thrombotic thrombocytopenic purpura (TTP) and benefit from therapeutic plasma exchange (TPE).
Koosha Paydary, Emma Banwell, Jiayi Tong, Yong Chen, A. Cuker   +4 more
semanticscholar   +1 more source

Thrombotic thrombocytopenic purpura

Disease-a-Month, 2014
Moschowitz first described thrombotic thrombocytopenic purpura (TTP) in 1925 in a 16-yearold female who presented with fever, petechiae, and a microangiopathic hemolytic anemia. Autopsy examination at the time revealed hyaline thrombi in the vascular beds of many organs. By 1947, several more cases were described and Singer suggested the term TTP.
Rami Y. Haddad, Robert Stein, Albara Said, Edgar V. Lerma   +3 more
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Thrombotic Thrombocytopenic Purpura

Archives of Internal Medicine, 1984
Freda Gardner, MD, Senior Assistant Resident, The Jewish Hospital of St Louis: A 42-year-old woman was in good health until four weeks prior to her admission, when she noted that minor trauma caused large ecchymotic lesions. One week prior to admission, she experienced the sudden onset of dysarthria, weakness and paresthesias of her right arm, light ...
Lorence A. Gutterman, Thomas D. Stevenson   +1 more
openaire   +3 more sources