Results 71 to 80 of about 94,849 (390)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Synchronization in multi-motor hydromechanical systems
Advanced Engineering Research, 2022 Introduction. The paper submits the analysis of existing design solutions of flow dividers used to synchronize hydraulic drives of working bodies of technological and mobile machines.
A. T. Rybak +3 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
STUDY OF FLUID OUTFLOW THROUGH THROTTLE CHANNELS WITH CAVITATION INITIATION
Вестник Донского государственного технического университета, 2018 The experimental study results of several hydrodynamic parameters of fluid discharge through the throttle channels of cylindrical or flat forms are offered.
Valery S. Kuznetsov
doaj
Flight test results for the Digital Integrated Automatic Landing Systems (DIALS): A modern control full-state feedback design [PDF]
, 1984 The Digital Integrated Automatic Landing System (DIALS) is discussed. The DIALS is a modern control theory design performing all the maneuver modes associated with current autoland systems: localizer capture and track, glideslope capture and track ...
Hueschen, R. M.
core +1 more source
Investigation of flow characteristics in the U-shaped throttle valve
Advances in Mechanical Engineering, 2019 Experimental and numerical analysis of cavitation flow in the U-shaped throttle valve is presented in this article. Cavitation flow has been analyzed numerically using the volume of fluid model while the pictures are captured by a high-speed camera.
Jie He, Beibei Li, Xiumei Liu
semanticscholar +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Derrotero, 2018 This paper describes the considerations taken into account in order to design and build an electronic control system to be used on an Unmanned Surface Vehicle (USV), in an effective, versatile and economic way, using Commercial Off-The-Shelf elements ...
Juan Pablo Gutiérrez Bucheli +1 more
doaj
Jurnal Teknik MesinThis study aims to investigate the effect of intake manifold and throttle body modifications on the performance of a Yamaha Mio M3 125cc motorcycle engine. A two-level factorial experimental design with two factors was employed: intake manifold diameter (
GUN GUN ANBIA
doaj +1 more source