Results 91 to 100 of about 7,801 (299)

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Advancing Dry Electroencephalography With Scalable, Soft, and Transcranial Magnetic Stimulation‐Compatible Ti3C2Tx MXene Electrodes for Research and Clinical‐Grade Applications

Advanced Science, EarlyView.
Dry soft Ti3C2Tx MXene electroencephalography (EEG) electrodes provide low impedance (2.1 ± 1.8 kΩ at 10 Hz), long‐term stability, and enable safe simultaneous EEG and transcranial magnetic stimulation (TMS). Across scalp sites, hair types, and recording paradigms, including steady state visual evoked potentials (SSVEP), clinical EEG, and mobile EEG ...
Sneha Shankar, Jakob Michiels, Ksenija Tasich, Ashley Koluda, Ryan Rich, Brian Erickson, Eugenia Angelopoulos, Francesca Cimino, Daryl Hurwitz, Raghav Garg, Spencer R. Averbeck, Doris Xu, Mariam Josyula, Nina Petillo, James J. Gugger, Kathryn A. Davis, John Medaglia, Flavia Vitale   +17 more
wiley   +1 more source

The safety and efficacy of five surgical treatments in prostate enucleation: a network meta-analysis

BMC Urology
Purpose The aim of our study was to investigate the comparative outcomes of five different energy types on surgical efficacy and postoperative recovery in patients with benign prostate hyperplasia.
Yun-Yi Chen, Wen-Xi Hua, Yu-Hua Huang, Xin-Yu Shen, Jia-Nan You, Xiang Ding   +5 more
doaj   +1 more source

Developmentally Inspired, Mechanical–Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening

Advanced Science, EarlyView.
A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Yurim Choi, Wonjun Jang, Raehui Kang, Ulziituya Batjargal, Jihyeon Song, Soojin Park, MinSeok Kim, Hyobum Cho, Junhyung Kim, Yu Shrike Zhang, Han‐Jun Kim, Junmin Lee   +11 more
wiley   +1 more source

Photon‐Sphere Modes in Curved Optical Microcavities: A Black‐Hole Analogue Laser

Advanced Science, EarlyView.
An optical analogue of a Schwarzschild black hole is realized using curved microcavities that preserve light‐like geodesics. A new family of laser modes confined around the photon sphere is identified alongside conventional whispering‐gallery modes. Analytical theory, numerical simulations, and experiments reveal curvature‐induced confinement, enabling
Chenni Xu, Aswathy Sundaresan, Nazire‐Begüm Kazkal, Clement Lafargue, Lior Zarfaty, Li‐Gang Wang, Ofek Birnholtz, Dominique Decanini, Melanie Lebental, Patrick Sebbah   +9 more
wiley   +1 more source

Repetition-Rate-Switchable and Self-Mode-Locked Pulses Generation From a Gain-Switched Thulium-Doped Fiber Laser and Their Amplification Properties

IEEE Photonics Journal, 2017
We report on repetition-rate-switchable and self-mode-locked pulses generation from a gain-switched thulium-doped fiber laser. Stable pulse trains were gain-switched by a home-made, pulsed Erbium/Ytterbium codoped fiber amplifier.
Deqin Ouyang, Junqing Zhao, Zhijian Zheng, Minqiu Liu, Shuangchen Ruan, Jihong Pei   +5 more
doaj   +1 more source

Broadband silica-based thulium doped fiber amplifier employing dual-wavelength pumping

, 2016
We report a broadband and gain-flattened silica-based thulium-doped fiber amplifier with dual-wavelength pumping (790nm + 1600nm). 15dB gain bandwidth is more than 220nm ranging from 1700 to 1920nm with a maximum gain of 29dB and a noise figure of less ...
Alam, Shaif-ul, Jung, Yongmin, Kang, Qiongyue, Liang, Sijing, Richardson, David, Wang, Junjia   +5 more
core   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Reconfigurable, Temperature Resilient Phase‐Change Metasurfaces Fabricated via High Throughput Nanoimprinting Lithography

Advanced Science, EarlyView.
ABSTRACT The combination of metasurfaces with chalcogenide phase‐change materials is a highly promising route toward the development of multifunctional and reconfigurable nanophotonic devices. However, their transition into real‐world devices is hindered by several technological challenges. This includes, amongst others, the lack of large area photonic
Carlota de Ruiz de Galarreta, Yinghao Zhao, Jose Mendoza‐Carreño, José M. Caicedo, José Santiso, C. David Wright, M. Isabel Alonso, Jiafang Li, Agustin Mihi   +8 more
wiley   +1 more source

Vestibular Schwannomas Microsurgery Assisted by Flexible Hand-Held 2 micro-Thulium-Fiber Laser

Caspian Journal of Neurological Sciences, 2016
Background: Vestibular Schwannoma (VS) is one of the skull base tumors originating from vestibular portion of eighth cranial nerve. Recently, 2 micro-Thulium laser is used in the surgery of some intracranial tumors. Objectives: Assessing the efficacy of
Luciano Mastronardi, Guglielmo Cacciotti, Raffaele Roperto, Maria Pia-Tonelli, Ettore Carpineta   +4 more
doaj