Results 61 to 70 of about 199,261 (304)

Kinetic Analysis of 2-[C]Thymidine PET Imaging Studies of Malignant Brain Tumors: Compartmental Model Investigation and Mathematical Analysis

Molecular Imaging, 2002
2-[ 11 C]Thymidine (TdR), a PET tracer for cellular proliferation, may be advantageous for monitoring brain tumor progression and response to therapy. We previously described and validated a five-compartment model for thymidine incorporation into DNA in ...
Joanne M. Wells, David A. Mankoff, Mark Muzi, Finbarr O'Sullivan, Janet F. Eary, Alexander M. Spence, Kenneth A. Krohn   +6 more
doaj   +1 more source

Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer

BMC Cancer, 2010
Background Biliary tract cancers have limitations in information about different location-related pathogenesis and clinico-pathological characteristics.
You Young, Kim Dong-Goo, Chung Eun-Seon, Lee Myung, Won Hye, Hong Tae, Lee In-Seok   +6 more
doaj   +1 more source

Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. [PDF]

PLoS ONE, 2011
BACKGROUND: The maintenance of the intestinal epithelium is of great importance for the survival of the organism. A possible nervous control of epithelial cell renewal was studied in rats and mice.
Ove Lundgren, Mats Jodal, Madeleine Jansson, Anders T Ryberg, Lennart Svensson   +4 more
doaj   +1 more source

Laser flash photolysis and magnetic-field-effect studies on interaction of thymine and thymidine with menadione: role of sugar in controlling reaction pattern

Science and Technology of Advanced Materials, 2008
The magnetic field effect (MFE) in conjunction with laser flash photolysis has been used for the study of the interaction of one of the small drug like quinone molecules, 2-methyl, 1,4-naphthoquinone, commonly known as menadione (MQ), with one of the DNA
Adity Bose, Debarati Dey and Samita Basu
doaj  

Kinetic Analysis of 2-[C]Thymidine PET Imaging Studies of Malignant Brain Tumors: Preliminary Patient Results

Molecular Imaging, 2002
2-[ 11 C]Thymidine (TdR), a PET tracer for cellular proliferation, may be advantageous for monitoring brain tumor progression and response to therapy. Kinetic analysis of dynamic TdR images was performed to estimate the rate of thymidine transport ( K 1t
Joanne M. Wells, David A. Mankoff, Janet F. Eary, Alexander M. Spence, Mark Muzi, Finbarr O'Sullivan, Cheryl B. Vernon, Jeanne M. Link, Kenneth A. Krohn   +8 more
doaj   +1 more source

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

Cardiovascular Diabetology, 2007
Background Inhibition of vascular smooth muscle cell (vSMC) proliferation by oral anti-hyperglycemic agents may have a role to play in the amelioration of vascular disease in diabetes.
de Dios Stephanie T, Osman Narin, Little Peter J, Cemerlang Nelly, Ballinger Mandy, Nigro Julie   +5 more
doaj   +1 more source

Contrasting ability to take up leucine and thymidine among freshwater bacterial groups: implications for bacterial production measurements

Environmental Microbiology, 2010
We examined the ability of different freshwater bacterial groups to take up leucine and thymidine in two lakes. Utilization of both substrates by freshwater bacteria was examined at the community level by looking at bulk incorporation rates and at the ...
M. Perez, P. Hörtnagl, R. Sommaruga
semanticscholar   +1 more source

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

The Anatomical Record, EarlyView.
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley   +1 more source

A Versatile Disulfide‐Containing Solid‐Support Strategy for 3′‐Modifiers in Oligonucleotides: Introducing Modular Tandem Oligonucleotide Synthesis

Chemistry – An Asian Journal, EarlyView.
We report a versatile disulfide‐containing linkage to solid support that enables on‐column synthesis of DNA and RNA containing a 3′‐amino or 3′‐phosphate group. This orthogonal solid‐support linker enables a protecting group strategy for the synthesis of oligonucleotides containing 3′‐amino‐2′,3′‐dideoxyribosides directly from commercially available ...
Jagandeep S. Saraya, Nicholas G. Horton, Michael J. Capperauld, Evan Zakaria, Derek K. O'Flaherty   +4 more
wiley   +1 more source

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

Proceedings of the National Academy of Sciences of the United States of America, 1996
In gene therapy to treat cancer, typically only a fraction of the tumor cells can be successfully transfected with a gene. However, in the case of brain tumor therapy with the thymidine kinase gene from herpes simplex virus (HSV-tk), not only the cells ...
M. Mesnil, C. Piccoli, G. Tiraby, K. Willecke, H. Yamasaki   +4 more
semanticscholar   +1 more source