PLoS ONE, 2019 Plasmodium falciparum thymidylate kinase (PfTMK) showed structural and catalytic distinctions from the host enzyme rendering it a hopeful antiprotozoal drug target.
Mahmoud Kandeel +3 more
doaj +1 more source
Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. [PDF]
PLoS ONE, 2011 BACKGROUND: The maintenance of the intestinal epithelium is of great importance for the survival of the organism. A possible nervous control of epithelial cell renewal was studied in rats and mice.
Ove Lundgren +4 more
doaj +1 more source
Nerve commitment in Hydra. II. Localization of commitment in S phase [PDF]
, 1981 The kinetics of nerve differentiation were investigated during head regeneration in Hydra. In particular the cell cycle parameters of stem cells undergoing nerve commitment were determined.
Berking +15 more
core +1 more source
Transcriptional profiling of thymidine-producing strain recombineered from Escherichia coli BL21
Genomics Data, 2015 DNA microarrays were used to compare the expression profiles of a thymidine overproducing strain (BLT013) and its isogenic parent, Escherichia coli BL21(DE3), when each was grown under well-defined thymidine production conditions with glycerol as carbon ...
Jin-Sook Kim +2 more
doaj +1 more source
Molecular Imaging, 2002 2-[ 11 C]Thymidine (TdR), a PET tracer for cellular proliferation, may be advantageous for monitoring brain tumor progression and response to therapy. Kinetic analysis of dynamic TdR images was performed to estimate the rate of thymidine transport ( K 1t
Joanne M. Wells +8 more
doaj +1 more source
Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2‐mutated fibroblasts [PDF]
The FEBS Journal, 2009 Mitochondrial thymidine kinase (TK2) catalyzes the phosphorylation of thymidine in mitochondria. Its function becomes essential for dTTP synthesis in noncycling cells, where cytosolic dTTP synthesis via R1/R2 ribonucleotide reductase and thymidine kinase 1 is turned down.
FRANGINI, MIRIAM +6 more
openaire +2 more sources
Different response to epidermal growth factor of hepatocytes in cultures isolated from male or female rat liver. Inhibitor effect of estrogen on binding and mitogenic effect of epidermal growth factor [PDF]
, 1987 Deoxyribonucleic acid (DNA) synthesis in hepatocytes isolated from the livers of male and female rats has been compared in monolayer culture. Plating efficiency, DNA and protein content, viability, and morphologic appearance were the same in cultures ...
Coetzee, M +8 more
core +1 more source
Limits of [18F]-FLT PET as a biomarker of proliferation in oncology. [PDF]
PLoS ONE, 2013 Non-invasive imaging biomarkers of cellular proliferation hold great promise for quantifying response to personalized medicine in oncology. An emerging approach to assess tumor proliferation utilizes the positron emission tomography (PET) tracer 3'-deoxy-
Eliot T McKinley +7 more
doaj +1 more source
THYMIDINE DEGRADATION PRODUCTS IN PLANT TISSUES LABELED WITH TRITIATED THYMIDINE [PDF]
The Journal of Cell Biology, 1963 A study of the metabolic pathways of H3-thymidine utilization in buds of Lilium longiflorum and root tips of Vicia faba was undertaken in order to obtain information that might explain the binding of H3 from H3-thymidine in the cytoplasm of these plants.
S T, TAKATS, R M, SMELLIE
openaire +2 more sources
Rabl's model of the interphase chromosome arrangement tested in Chinise hamster cells by premature chromosome condensation and laser-UV-microbeam experiments [PDF]
, 1982 In 1885 Carl Rabl published his theory on the internal structure of the interphase nucleus. We have tested two predictions of this theory in fibroblasts grown in vitro from a female Chinese hamster, namely (1) the Rabl-orientation of interphase ...
C Cremer +34 more
core +1 more source