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The Thyroid-Stimulating Hormone Receptor: Impact of Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Antibodies on Multimerization, Cleavage, and Signaling

Endocrinology and Metabolism Clinics of North America, 2009
The thyroid-stimulating hormone receptor (TSHR) has a central role in thyrocyte function and is also one of the major autoantigens for the autoimmune thyroid diseases. We review the post-translational processing, multimerization, and intramolecular cleavage of TSHR, all of which may modulate its signal transduction.
Rauf, Latif   +3 more
openaire   +2 more sources

A water-soluble fragment of the thyroid-stimulating hormone receptor which binds both thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies

Journal of Endocrinology, 1984
ABSTRACT Previous studies have shown that freezing and thawing of human thyroid homogenates releases a water-soluble substance which reversibly binds to TSH-receptor antibodies. This substance has been designated long-acting thyroid stimulator absorbing activity (LAA).
E, Davies Jones, B, Rees Smith
openaire   +2 more sources

An immunoglobulin G complexed form of thyroid-stimulating hormone (macro thyroid-stimulating hormone) is a cause of elevated serum thyroid-stimulating hormone concentration

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2013
Background Macrocomplexes can be the cause of elevated serum hormone concentrations and may cause diagnostic confusion. This is well recognized for prolactin and commonly screened for using polyethylene glycol (PEG) precipitation.
Francesca, Mills   +4 more
openaire   +2 more sources

Inappropriate Secretion of Thyroid-Stimulating Hormone

Annals of Internal Medicine, 1981
Recent studies have provided major new insights into the syndromes of inappropriate secretion of thyroid-stimulating hormone (TSH), a heterogeneous group of disorders in which patients show inappropriately elevated levels of serum immunoactive TSH in the presence of elevated free thyroid hormone levels.
BRUCE D. WEINTRAUB   +3 more
openaire   +2 more sources

Pituitary thyroid-stimulating hormone and thyroid-stimulating immunoglobulins

1976
Thyroid function can be stimulated by several macromolecules, including pituitary thyroid-stimulating hormone (TSH), human chorionic thyrotrophin (HCT), human molar thyrotophin (HMT) and a population of thyroid-stimulating immunoglobulins. This paper attempts to review concisely the properties of these thyroid stimulators.
B. R. Smith, R. Hall
openaire   +1 more source

Crystallization of Bovine Thyroid Stimulating Hormone

Endocrinology, 1967
Bovine thyroid stimulating hormone was extracted with ammonium sulfate solutions of decreasing concentrations. Crystals of the hormone separated upon storage of the extracts at room temperature. (Endocrinology 80: 203, 1967)
P, Condliffe, W B, Jakoby
openaire   +2 more sources

Thyroid Stimulating Hormone

1994
A glycopeptide (M.Wt. 32 kDa) containing approximately 16% carbohydrate, secreted by the thyrotrophs of the anterior pituitary.
openaire   +1 more source

Interference in thyroid‐stimulating hormone determination

European Journal of Clinical Investigation, 2010
Eur J Clin Invest 2010; 40 (8): 756–758AbstractBackground  Thyroid‐stimulating hormone (TSH) measurement plays a major role in the diagnosis of thyroid disorders. Despite the good quality of immunochemical tests measuring TSH levels, the presence of interfering substances can sometimes alter the TSH results.Design  We reported the case of a 79‐year‐old
Imperiali M   +6 more
openaire   +3 more sources

Thyroid-stimulating hormone pituitary adenomas

Journal of Neurosurgery, 2008
Object Thyroid-stimulating hormone (TSH)–secreting pituitary adenomas are rare, representing < 2% of all pituitary adenomas. Methods The authors conducted a retrospective analysis of patients with TSH-secreting or clinically silent TSH-immunostaining pituitary tumors among all pituitary adenomas followed at their institution between 1987 and 2003.
Michelle J, Clarke   +3 more
openaire   +2 more sources

THYROID-STIMULATING HORMONE

British Medical Bulletin, 1960
H D, PURVES, D D, ADAMS
openaire   +2 more sources

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