Results 91 to 100 of about 254,610 (274)

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source

Brown adipose tissue and regulation of human body weight

Diabetes/Metabolism Research and Reviews, Volume 39, Issue 1, January 2023., 2023
Abstract Background Approximately 30% of the global population is affected by obesity. Traditional non‐surgical measures for weight loss have limited efficacy and tolerability. Therefore, there is a need for novel, effective therapies. Brown adipose tissue (BAT) has been implicated in physiological energy expenditure, indicating that it could be ...
Elissa Harb, Omar Kheder, Gishani Poopalasingam, Razi Rashid, Akash Srinivasan, Chioma Izzi‐Engbeaya   +5 more
wiley   +1 more source

The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation–Ubiquitylation Crosstalk of HMGA2

Advanced Science, EarlyView.
Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu, Zhangjin Shen, Shizhen Shen, Conghui Wang, Yuwan Liu, Xinyi Wei, Mengxia Zheng, Jiaxin Gu, Xiaojing Chen, Yi Sun, Junfen Xu, Yan Lu, Weiguo Lu   +12 more
wiley   +1 more source

AKT1E17K‐Interacting lncRNA SVIL‐AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation

Advanced Science, EarlyView.
Wang et al. discover a novel lncRNA regulator of mutant oncoprotein which prevents AKT1E17K dephosphorylation. SVIL‐AS1 overexpression correlates with poor prognosis of breast cancer patients. It interacts with AKT1E17K protein and impedes PP2A holoenzyme from dephosphorylating AKT1 by blocking the binding of the regulatory subunit PPP2R2A to AKT1 ...
Jingyi Wang, Wenying Chen, Qianying Li, Ruiyi Yang, Xiaorong Lin, Ping Han, Xiaoming Huang, Hai Hu, Man‐Li Luo   +8 more
wiley   +1 more source

Porous Aromatic Framework with Multifunctional Sites for Effective Recovery of Various Trace Iodine Species From Water

Advanced Science, EarlyView.
A PAF adsorbent with multifunctional sites framework is developed for the recovery of environment iodine. Benefiting from the high density and accessibility of the favorable Coulomb interaction sites for iodide (I3− and I−) as well as the charge transfer sites for iodine molecules (I2), the PAF adsorbent realizes recording adsorption capacity for ...
Yue Ma, Jinjiao Pan, Huazhen Rong, Yilei Zhang, Lu Liu, Yu Guo, Jiayi Ai, Yihui Yuan, Ning Wang   +8 more
wiley   +1 more source

Think-aloud approach combined with case-based learning in nursing teaching round for new nurses in cancer hospital

BMC Medical Education
Background The transition from nursing students to working as new nurses can be a challenging process. This study aimed to assess the efficacy of a pedagogical approach amalgamating the think-aloud approach and case-based learning in the instructional ...
Rui Zhao, TingTing Ding, JinPing Meng, Miao Lei, Huili Ma   +4 more
doaj   +1 more source

Papillary cancer of the thyroid. A review of 25 years of experience [PDF]

, 1958
Edgar L. Frazell, Frank W. Foote
openalex   +1 more source

Effect of Intraoperative Posture on Accurate Diagnostic Rate of Intraoperative Nerve Monitoring During Esophagectomy

Annals of Gastroenterological Surgery, EarlyView.
Adequate contact between the intubation tube and the vocal cord muscles is crucial for effective intraoperative nerve monitoring use during esophagectomy. Additionally, intraoperative posture significantly affects diagnostic outcomes and should be carefully considered.
Masami Yuda, Keita Takahashi, Yoshitaka Ishikawa, Takanori Kurogochi, Akira Matsumoto, Naoko Fukushima, Takahiro Masuda, Naoto Takahashi, Fumiaki Yano, Ken Eto   +9 more
wiley   +1 more source

Postoperative rehabilitation and quality of life evaluation for transoral endoscopic thyroidectomy vestibular approach

Scientific Reports
There are no targeted rehabilitation training modalities and assessment tools for patients after transoral endoscopic thyroidectomy vestibular approach (TOETVA).
Yu Mao, Shiwei Zhou, Peng Wu, Wu Li, Hui Li, Zhiyuan Wang, Xibin Xia, Xiaohua Song, Mingming Wang, Xiaowei Peng   +9 more
doaj   +1 more source

Beyond the Nucleus: Cytoplasmic Dominance in Follicular Thyroid Carcinoma Detection Using Single-Cell Raman Imaging Across Multiple Devices [PDF]

arXiv, 2019
Cytological diagnosis of follicular thyroid carcinoma (FTC) is one of major challenges in the field of endocrine oncology due to absence of evident morphological indicators. Morphological abnormalities in the nucleus are typically key indicators in cancer cytopathology and are attributed to a range of biochemical alterations in nuclear components ...
arxiv