Results 91 to 100 of about 447,839 (304)

Sentinel lymph node biopsy in cT1-2N0 lip squamous cell carcinoma: site-specific diagnostic accuracy, anatomic mapping, and survival impact

BMC Oral Health
Background Optimal management of the clinically node-negative (cN0) neck in early-stage (cT1-2) lip squamous cell carcinoma (SCC) remains controversial.
Yanyan Liu, Man Yang, Yunli Fan, Wei Du
doaj   +1 more source

Galectin-3 performance in histologic and cytologic assessment of thyroid nodules. A systematic review and meta-analysis [PDF]

, 2017
The literature on Galectin-3 (Gal-3) was systematically reviewed to achieve more robust information on its histologic reliability in identifying thyroid cancers and on the concordance between Gal-3 test in histologic and cytologic samples.
Crescenzi, Anna, Giovanella, Luca, Romanelli, Francesco, Trimboli, Pierpaolo, Virili, Camilla   +4 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy. [PDF]

, 2016
Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-).
Ahmad, Ahn, Carlson, Carrasco, Carrasco, Carrasco, Carrasco, Carrasco, Clarke, Desai, Dirbas, Dominguez, Gambhir, Gonzalez-Angulo, Grollman, Harrington, Haveman, Ikeda, Jhiang, Jhiang, Jhiang, Kalkanis, Kang, Kirova, Lawrence, Lawrence, Lind, Link, Liu, Lorusso, Mier, Morris, Neuwelt, Nishimura, Russell, Schlumberger, Seidman, Smith, Spitzweg, Steeg, Studebaker, Vermorken, Vermorken, Wapnir, Wapnir, Wapnir, Wapnir   +46 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Tyrosine kinase inhibitors for the therapy of anaplastic thyroid cancer [PDF]

, 2015
Anaplastic thyroid cancer (ATC) is often incurable so new therapeutic approaches are needed. Tyrosine kinases inhibitors (such as imanitib, sunitinib or sorafenib) are under evaluation for the treatment of ATC.
Bond JA, Cohen EE, Dowlati A, Goulart B, Grande E, Hayashi N, Ibrahim N, Klopper JP, Mahlknecht U, Ohta K, Ruggeri RM, Sherman SI   +11 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Whole breast and regional nodal irradiation in prone versus supine position in left sided breast cancer [PDF]

, 2017
Background: Prone whole breast irradiation (WBI) leads to reduced heart and lung doses in breast cancer patients receiving adjuvant radiotherapy. In this feasibility trial, we investigated the prone position for whole breast + lymph node irradiation (WB +
A Berrington de Gonzalez, AM Kirby, Annick Van Greveling, Bert Boute, Bruno Speleers, BT Gielda, BV Offersen, BV Offersen, Chris Monten, CR Jephcott, FR Bartlett, FR Bartlett, G Alco, Giselle Post, Herman Depypere, I Finke, IR Vogelius, IY Jo, J Buijsen, J Reznik, JD Boice Jr, Joris Van de Velde, K Kainz, K Verhoeven, K Verhoeven, L Veldeman, LB Marks, LB Thorsen, Leen Paelinck, Liv Veldeman, LM Sun, M Alonso-Basanta, M Feng, M Stovall, N Dogan, N Mason, P McGale, PD Inskip, Pieter Deseyne, PM Poortmans, RA Sethi, SC Darby, SC Formenti, SC Lymberis, SM Shin, T Grantzau, T Grantzau, T Mulliez, T Mulliez, T Mulliez, T Mulliez, T Viren, TE Merchant, TJ Whelan, Tom Van Hoof, Wilfried De Neve, X Gao   +56 more
core   +2 more sources

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Development and validation of a nomogram to predict failure of initial radioactive iodine therapy in differentiated thyroid cancer: a retrospective cohort study

Scientific Reports
Given the scarcity of studies predicting iodine-131 treatment failure based on clinicopathological factors, this study aimed to determine whether clinicopathological features can predict iodine-131 treatment failure in differentiated thyroid carcinoma ...
Yulong Tang, Peng Wu, Shiwei Zhou, Hui Li, Xiaohua Song, Wu Li, Xiaowei Peng   +6 more
doaj   +1 more source