Results 151 to 160 of about 5,157,057 (389)

Safety and antitumor activity of the anti–PD-1 antibody pembrolizumab in patients with advanced, PD-L1–positive papillary or follicular thyroid cancer

BMC Cancer, 2019
Treatment options for advanced thyroid cancer refractory to standard therapies are limited. The safety and efficacy of pembrolizumab were evaluated in patients with advanced differentiated thyroid cancer expressing programmed death ligand 1 (PD-L1 ...
J. Mehnert, A. Varga, M. Brose, R. Aggarwal, Chia‐Chi Lin, A. Prawira, F. D. De Braud, K. Tamura, T. Doi, S. Piha-Paul, J. Gilbert, S. Saraf, P. Thanigaimani, Jonathan D. Cheng, B. Keam   +14 more
semanticscholar   +1 more source

Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]

, 2018
The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć, Kamila Kozłowska, Marta Ząbczyńska   +2 more
core   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

Think-aloud approach combined with case-based learning in nursing teaching round for new nurses in cancer hospital

BMC Medical Education
Background The transition from nursing students to working as new nurses can be a challenging process. This study aimed to assess the efficacy of a pedagogical approach amalgamating the think-aloud approach and case-based learning in the instructional ...
Rui Zhao, TingTing Ding, JinPing Meng, Miao Lei, Huili Ma   +4 more
doaj   +1 more source

Risk Stratification in Differentiated Thyroid Cancer: From Detection to Final Follow-up.

Journal of Clinical Endocrinology and Metabolism, 2019
CONTEXT Modern management of differentiated thyroid cancer requires individualized care plans which tailor the intensity of therapy and follow-up to the estimated risks of recurrence and disease-specific mortality.
R. M. Tuttle, A. S. Alzahrani
semanticscholar   +1 more source

Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions. [PDF]

, 2019
Palpable thyroid lesions are common, and although mostly benign, lethal malignant nodules do occur and may be difficult to differentiate. Here, we introduce the use of a piezoelectric system called Smart-touch fine needle (or STFN) mounted directly onto ...
Aguilera, Renato, Gimzewski, James K, Rao, JianYu, Sharma, Shivani   +3 more
core  

IGF-I influences everolimus activity in medullary thyroid carcinoma [PDF]

, 2015
Context: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cells. It has been previously demonstrated that insulin-like growth factor I (IGF-I) protects MTC from the effects of antiproliferative drugs. Everolimus,
degli Uberti, Ettore C., Di Pasquale, Carmelina, Gagliano, Teresa, GENTILIN, ERICA, MERANTE BOSCHIN, ISABELLA, Pelizzo, Mariarosa, Rossi, Martina, Rossi, Roberta, Tagliati, Federico, Zatelli, Maria Chiara   +9 more
core   +1 more source

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

Advanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan, Xinbo Zhao, Xuejie Han, Yukai Cao, Xuexin Jin, Ling Shi, Xin Bi, Desheng Li, Yun Zhang, Wenbo Ma, Jiahui Song, Zhenwei Pan, Zhiren Zhang, Yue Li   +13 more
wiley   +1 more source

Lymph node metastasis in cutaneous squamous cell carcinoma of the head and neck

BMC Cancer
Background The study aimed to assess the impact of parotid lymph nodes (LNs) on the prognosis of patients with cutaneous squamous cell carcinomas of the head and neck (HNcSCC), and to develop an alternative LN assessment method to enhance locoregional ...
Qigen Fang, Junhui Yuan, Xu Zhang, Liyuan Dai, Ruihua Luo   +4 more
doaj   +1 more source

A Phase II study of the safety and efficacy of lenvatinib in patients with advanced thyroid cancer.

Future Oncology, 2019
AIM To investigate the safety and efficacy of lenvatinib in advanced thyroid cancer. PATIENTS/METHODS In this Phase II study, 51 Japanese patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC), medullary thyroid cancer (MTC) or ...
S. Takahashi, N. Kiyota, T. Yamazaki, N. Chayahara, K. Nakano, L. Inagaki, Kazuhisa Toda, T. Enokida, H. Minami, Y. Imamura, N. Fukuda, Tatsuya Sasaki, Takuya Suzuki, H. Ikezawa, C. Dutcus, M. Tahara   +15 more
semanticscholar   +1 more source