Results 61 to 70 of about 5,282,014 (364)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Preoperative Ultrasonography Predicts Level II Lymph Node Metastasis in N1b Papillary Thyroid Carcinoma: Implications for Surgical Planning

Biomedicines
Purpose: To investigate whether preoperative ultrasonographic (US) features of the index cancer and metastatic lymph nodes (LNs) are associated with level II LN metastasis in N1b papillary rmfthyroid carcinoma (PTC) patients.
Na Lae Eun, Jeong-Ah Kim, Yangkyu Lee, Ji Hyun Youk, Hyeok Jun Yun, Hojin Chang, Seok-Mo Kim, Yong Sang Lee, Hang-Seok Chang, Hyejin Yang, Soyoung Jeon, Eun Ju Son   +11 more
doaj   +1 more source

Thyroid cancer and nonsteroidal anti-inflammatory drug use: a pooled analysis of patients older than 40 years of age [PDF]

, 2015
Background: Cyclooxygenase (COX-2) has been associated with tumor growth and metastasis in several cancers, including thyroid cancer. For this reason, several investigators have studied COX-2 inhibitors in preclinical models of thyroid cancer and found ...
Kebebew, Electron, Kitahara, Cari M, Liao, Linda M, Linet, Martha, Nilubol, Naris, Park, Yikyung, Patel, Dhaval   +6 more
core   +2 more sources

Updates on the Management of Thyroid Cancer

Hormone and Metabolic Research, 2020
The diagnostic modalities, stratification tools, and treatment options for patients with thyroid cancer have rapidly evolved since the development of the American Thyroid Association (ATA) guidelines in 2015.
Katherine Araque, Sriram Gubbi, J. Klubo-Gwiezdzinska   +2 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Comparison of the degree of patient satisfaction between transoral thyroidectomy and open thyroidectomy: a survey-based study

BMC Surgery
Background Recent advances in thyroid surgery techniques have increased the number of patients undergoing transoral thyroidectomy, and many patients are concerned about post-thyroidectomy cosmetic effects. This study aimed to compare patient satisfaction
Jun Sung Lee, Jooyoung Oh, Jayyoung Bae, Jin Seok Lee, Hyeok Jun Yun, Seok-Mo Kim, Hojin Chang, Yong Sang Lee, Young Song, Hang-Seok Chang   +9 more
doaj   +1 more source

SoLAT (Sorafenib Lenvatinib alternating treatment): a new treatment protocol with alternating Sorafenib and Lenvatinib for refractory thyroid Cancer

BMC Cancer, 2018
Background In the last decade, several tyrosine kinase inhibitors (TKIs), which disrupt pathways involved in the proliferation and tumorigenesis of thyroid cancer, have been extensively studied. Two different TKIs, lenvatinib and sorafenib, were recently
Soo Young Kim, Seok-Mo Kim, Ho-Jin Chang, Bup-Woo Kim, Yong Sang Lee, Cheong Soo Park, Ki Cheong Park, Hang-Seok Chang   +7 more
doaj   +1 more source

Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and Migration [PDF]

, 2017
Tumor stroma-secreted growth factors, cytokines, and reactive oxygen species (ROS) influence tumor development from early stages to the metastasis phase.
Cantu, D., CAPPELLO, Francesco, Castellone, M., Chen, H., Hematti, P., Kim, J., Laukkanen, M., Mazzoccoli, G., Parascandolo, A., RAPPA, Francesca, Salvatore, M.   +10 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Survival With Lenvatinib for the Treatment of Progressive Anaplastic Thyroid Cancer: A Single-Center, Retrospective Analysis

Frontiers in Endocrinology, 2020
Background: Survival rates for anaplastic thyroid cancer (ATC) have not improved in the past four decades; however, preliminary clinical data indicate that lenvatinib may provide efficacy benefits for patients with ATC.
Soo Young Kim, Seok-Mo Kim, Jun Won Kim, Ik Jae Lee, Tae Joo Jeon, Hojin Chang, Bup-Woo Kim, Yong Sang Lee, Hang-Seok Chang, Cheong Soo Park   +9 more
doaj   +1 more source