Results 61 to 70 of about 254,610 (274)

miR-221/222 sponge abrogates tamoxifen resistance in ER-positive breast cancer cells through restoring the expression of ERα

Molecular Biomedicine, 2021
Tamoxifen resistance (TamR) prevents ER-positive breast cancer patients from benefitting from endocrine therapy, and miR-221 or miR-222 plays vital roles in inducing TamR.
Yan Xiu Ouyang, Jun Feng, Zun Wang, Guo Jun Zhang, Min Chen   +4 more
doaj   +1 more source

CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor‐Associated Macrophages to Promote Tumor Progression

Advanced Science, EarlyView.
This study elucidates the crosstalk between tumor‐associated macrophages (TAMs) and anaplastic thyroid cancer stem cells (ATCSCs). The findings reveal that CCL20 from THP‐1‐M2 activates the IRAK‐1/NF‐κB1/2 pathway in ATCSCs, thereby enhancing CXCL5 secretion.
Qi Liu, Yan Wang, Mingyuan Song, Jiapeng Huang, Jinyuan Shi, Wei Sun, Xiaoyu Ji, Yuang Chang, Bing Ma, Ping Zhang, Yuanyuan Yan, Hao Zhang   +11 more
wiley   +1 more source

Minimal residual disease assessment of papillary thyroid carcinoma through circulating tumor cell‐based cytology

Cancer Medicine, Volume 11, Issue 24, Page 4830-4837, December 2022., 2022
minimal residual disease assessment in post surgery patients with papillary thyroid cancer through CTCs‐based cytology Abstract The overall estimated risk of recurrence after an apparently complete thyroid cancer resection ranges from <1% to 55%, and the high‐quality pathology report is crucial for proper risk stratification.
Nadia Innaro, Rita Gervasi, Teresa Ferrazzo, Nastassia C. Garo, Lucia S. Curto, Annamaria Lavecchia, Isabella Aquila, Giuseppe Donato, Natalia Malara   +8 more
wiley   +1 more source

Segmentation of ultrasound images of thyroid nodule for assisting fine needle aspiration cytology [PDF]

arXiv, 2012
The incidence of thyroid nodule is very high and generally increases with the age. Thyroid nodule may presage the emergence of thyroid cancer. The thyroid nodule can be completely cured if detected early. Fine needle aspiration cytology is a recognized early diagnosis method of thyroid nodule.
arxiv  

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

European multicentre study on outcome of surgery for sporadic primary hyperparathyroidism

BJS (British Journal of Surgery), EarlyView., 2020
Some 5861 patients undergoing first‐time surgery for sporadic primary hyperparathyroidism were registered in the Eurocrine® database between 2015 and 2018. The use of intraoperative parathyroid hormone measurement decreased the risk of conversion and persistent hypercalcaemia.
A. Bergenfelz, S. van Slycke, Ö. Makay, L. Brunaud   +3 more
wiley   +1 more source

One‐year COVID‐19 outcomes on the oncology care patient pathway: Results of a French descriptive, cross‐sectional comprehensive study (ONCOCARE‐COV)

Cancer Medicine, Volume 11, Issue 24, Page 4865-4879, December 2022., 2022
Key steps in the oncology care pathway activity were retrospectively analyzed and compared in this comprehensive and cross‐sectional study, between the different time settings in the COVID‐19 pandemic. Oncology care were heavily disrupted during the first and second COVID‐19 outbreak waves with decrease in screening and diagnosis activity as well as an
Léonard Laurent, Mathias Brugel, Claire Carlier, Florentin Clere, Aurélie Bertrand, Damien Botsen, Camille Boulagnon‐Rombi, Véronique Dalstein, Adeline Debreuve‐Theresette, Sophie Deguelte, Christian Garbar, Rachid Mahmoudi, Antonin Marechal, David Morland, Jean‐Baptiste Rey, Claire Schvartz, Catherine Vallet, Yacine Merrouche, Florian Slimano, Olivier Bouché   +19 more
wiley   +1 more source

Optimizing surgical outcomes in papillary thyroid carcinoma with Hashimoto’s Thyroiditis: a retrospective comparative study of unilateral and total thyroidectomy

Scientific Reports
The management of papillary thyroid carcinoma (PTC) concurrent with Hashimoto’s thyroiditis (HT) lacks standardized guidelines, especially concerning surgical strategies. This study aimed to compare unilateral thyroidectomy (UT) with total thyroidectomy (
Xiaoyong Wen, Shiwei Zhou, Wu Li, Hui Li, Xiaohua Song, Yu Mao, Zeyu Li, Guangji Chen, Xiaowei Peng, Peng Wu   +9 more
doaj   +1 more source

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
wiley   +1 more source

Central lymph node dissection and permanent hypoparathyroidism after total thyroidectomy for papillary thyroid cancer: population‐based study

BJS (British Journal of Surgery), EarlyView., 2020
Papillary thyroid carcinoma is treated with thyroidectomy with or without central lymph node dissection (CLND). The risk of permanent hypoparathyroidism after CLND was calculated. The results that indicated that CLND is an independent risk factor for permanent hypoparathyroidism. CLND is associated with permanent hypoparathyroidism Background Papillary
F. A. Salem, A. Bergenfelz, E. Nordenström, M. Almquist   +3 more
wiley   +1 more source