NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G [PDF]
, 2009 Background: The activating immunoreceptor NKG2D is expressed on Natural Killer (NK) cells and subsets of T cells. NKG2D contributes to anti-tumour and anti-viral immune responses in vitro and in vivo. The ligands for NKG2D in humans are diverse proteins
A Cerwenka +67 more
core +11 more sources
Bilaterality as a Risk Factor for Recurrence in Papillary Thyroid Carcinoma [PDF]
, 2023 Hyeji Kim, Hyungju Kwon
openalex +1 more source
Advanced Science, EarlyView.This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu +10 more
wiley +1 more source
Update on epidemiology classification, and management of thyroid cancer [PDF]
Libyan Journal of Medicine, 2006 Thyroid cancer represents approximately 0.5–1% of all human malignancy1. In the UK the incidence of thyroid cancer is 2-3 per 100,000 populations 2. In geographical areas of low iodine intake and in areas exposed to nuclear disasters the incidence of ...
Heitham Gheriani
doaj
miR‐671‐5p repressed progression of papillary thyroid carcinoma via TRIM14
Kaohsiung Journal of Medical Sciences, 2021 The pivotal role of dysregulated miRNAs in development of papillary thyroid carcinoma has been emphasized in recent research. miR‐671‐5p was previously documented to function as a tumor suppressor.
Wan‐Ju Wang +4 more
doaj +1 more source
IGF-I influences everolimus activity in medullary thyroid carcinoma [PDF]
, 2015 Context: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cells. It has been previously demonstrated that insulin-like growth factor I (IGF-I) protects MTC from the effects of antiproliferative drugs. Everolimus,
degli Uberti, Ettore C. +9 more
core +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Analysis of thyroid carcinomas with immunohistochemical panel application: retrospectively study of 52 cases [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2019 Aim: The aim of this study was to share our cases of thyroid carcinoma with the literature and to emphasize the importance of evaluation with an immunohistochemical panel in cases with difficulty in the differential diagnosis.
Mecdi Gurhan Balci, Mahir Tayfur
doaj +1 more source
Functional characterization of human thyroid tissue with immunohistochemistry [PDF]
, 2007 Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases.
Bernard, Caillou +6 more
core +1 more source