Results 41 to 50 of about 299,100 (307)

CTLA-4 and PD-1 ligand gene expression in epithelial thyroid cancers [PDF]

, 2018
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance. Here, the expression of PD-L1, PD-L2, CD80 and CD86 was evaluated at mRNA level in 94 patients affected ...
Antonelli, Alessandro, Arcieri, Stefano, Baldini, Enke, Barollo, Susi, Carbotta, Giovanni, Catania, Antonio, Fallahi, Poupak, Mian, Caterina, Monti, Massimo, Palmieri, Andrea, Pironi, Daniele, Sorrenti, Salvatore, Tartaglia, Francesco, Tuccilli, Chiara, Ulisse, Salvatore, Vergine, Massimo   +15 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Potential functions and mechanisms of lysine crotonylation modification (Kcr) in tumorigenesis and lymphatic metastasis of papillary thyroid cancer (PTC)

Journal of Translational Medicine
Objectives To examine the putative functions and mechanisms of lysine crotonylation (Kcr) during the development and progression of papillary thyroid cancer (PTC).
Zhaokun Li, Jingting Li, Fang Li, Liang Han, Chengqiu Sui, Le Zhou, Daqi Zhang, Yantao Fu, Rui Du, Jiedong Kou, Gianlorenzo Dionigi, Hui Sun, Nan Liang   +12 more
doaj   +1 more source

Case reports of collision and composite carcinomas of the thyroid: an insight into their origin and clinical significance

BMC Endocrine Disorders, 2023
Background Collision and composite carcinomas of the thyroid are extremely rare, and their clinical and biological characteristics are poorly understood.
Tao Ma, Ruixiao Wang, Xu Zhou, Liqiang Liu, Aijing Pan, Hongmei Wang, Lingyan Huang   +6 more
doaj   +1 more source

Diffuse sclerosing variant of thyroid carcinoma presenting as Hashimoto thyroiditis: a case report [Difuzno sklerozirajući oblik papilarnog karcinoma štitnjače nalik Hashimoto tireoiditisu: prikaz slučaja] [PDF]

, 2012
The aim of report is to present a case of a rare diffuse sclerosing variant of a papillary thyroid carcinoma. A 15-year old girl referred for ultrasound examination because of painless thyroid swelling lasting 10 days before.
Banek, Tomislav, Kusačić Kuna, Sanja, Prgomet, Drago, Trutin Ostović, Karmen, Vukasović, Anamarija   +4 more
core  

Recent advances in managing differentiated thyroid cancer [PDF]

, 2018
The main clinical challenge in the management of thyroid cancer is to avoid over-treatment and over-diagnosis in patients with lower-risk disease while promptly identifying those patients with more advanced or high-risk disease requiring aggressive ...
Durante, Cosimo, Filetti, Sebastiano, Grani, Giorgio, Lamartina, Livia   +3 more
core   +2 more sources

Incidental Thyroid Carcinoma [PDF]

Indian Journal of Otolaryngology and Head & Neck Surgery, 2012
to find out the frequency of incidental thyroid carcinoma (ITC) in patients presumably operated for benign thyroid diseases.a total of 187 patients undergoing surgery for benign thyroid diseases were included in the study. All the patients underwent fine needle aspiration cytology (FNAC). Only those with benign diseases on FNAC were studied.
Nikhil, Nanjappa, Abhilash, Kumar, Sudeepta Kumar, Swain, T Tirou, Aroul, S Robinson, Smile, Dhananjay, Kotasthane   +5 more
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Complications after medullary thyroid carcinoma surgery: multicentre study of the SQRTPA and EUROCRINE® databases

BJS (British Journal of Surgery), EarlyView., 2020
This study investigated postoperative complications after surgery for medullary thyroid carcinoma (MTC) in Europe. Hypoparathyroidism, recurrent laryngeal nerve palsy and bleeding requiring reoperation occurred in 170 (26·2 per cent), 62 (13·7 per cent) and 17 (2·6 per cent) patients respectively.
D.‐J. van Beek, M. Almquist, A. O. Bergenfelz, T. J. Musholt, E. Nordenström, on behalf of the EUROCRINE® Council, M. Almquist, M. Barczynski, L. Brunaud, T. Clerici, M. H. Hansen, M. Iacobone, Ö. Makay, F. F. Palazzo, N. Muñoz‐Pérez, M. Raffaelli, P. Riss, S. van Slycke, M. R. Vriens   +18 more
wiley   +1 more source

Medullary thyroid carcinoma

American Journal of Otolaryngology, 1993
Medullary thyroid carcinoma (MTC) comprises approximately 1–2% of thyroid malignancies and occurs in sporadic and heritable forms. Hereditary forms include multiple endocrine neoplasia (MEN) type 2A, familial medullary thyroid carcinoma (FMTC), and MEN type 2B.
Y L, Colson, S E, Carty
openaire   +4 more sources