Results 131 to 140 of about 9,788,907 (408)

Extracellular Vesicular Delta‐Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis

Advanced Science, EarlyView.
Small cell lung cancer (SCLC) harbors high molecular heterogeneity. Using a new liquid biopsy assay, SCLC subtypes can be identified by measuring mRNA of subtype transcription factors (ASCL1, POU2F3, and NEUROD1) in exosome‐rich extracellular vesicles. Combining with Delta‐like ligand 3 (DLL3) mRNA in exosomes and its membrane protein in extracellular ...
Hong Li, Chi‐Ling Chiang, Kwang Joo Kwak, Hsin‐Lun Lee, Xinyu Wang, Giulia Romano, Michela Saviana, Robin Toft, Tai‐Shan Cheng, Yuehshih Chang, Bi‐Da Hsiang, Guan‐Wan Liu, Xiaokui Mo, Yifan Ma, Junjie Pan, Xilal Y. Rima, Truc Nguyen Kim, Eduardo Reategui, Chia‐Ning Shen, Yeh‐Shiu Chu, Carlo Croce, Peter Mu‐Hsin Chang, Yi‐Chen Yeh, David P. Carbone, Chi‐Ying F. Huang, Chi‐Lu Chiang, Patrick Nana‐Sinkam, L. James Lee   +27 more
wiley   +1 more source

Unveiling the link: anti-protein disulfide isomerase A3 autoantibody expression and polycystic ovary syndrome risk in euthyroid autoimmune thyroiditis women

Journal of Ovarian Research
Background Polycystic ovary syndrome (PCOS) is a common complication of autoimmune thyroiditis (AIT) in women, but the underlying mechanism remains unclear. Protein disulfide isomerase A3 (PDIA3) is a ubiquitous protein.
Zhaoying Chen, Chenxi Zhang, Chunfeng Meng, Yadan Hu, Yazhuo Niu, Bingrui Gao, Jinshuo Wang, Lu Liu, Kan Chen, Zhongyan Shan, Weiping Teng, Jing Li   +11 more
doaj   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

Parathyroid Double Adenoma Associated with Papillary Carcinoma of Thyroid [PDF]

It has been reported that thyroid disease is common in patients with hyperparathyroidism, and vice versa. Parathyroid adenoma is the most common cause of primary hyperparathyroidism (PHPT).
ایرانپرور, منوچهر, دادخواه, مینو, رستمی, خلیل, پورفرضی, فرهاد   +3 more
core  

Accurate and Noninvasive Dysphagia Assessment via a Soft High‐Density sEMG Electrode Array Conformal to the Submental and Infrahyoid Muscles

Advanced Science, EarlyView.
A stretchable, breathable, large‐area high‐density sEMG (HD‐sEMG) electrode array is reported, which enables seamless integration to the complex surface of the submental and infrahyoid muscles to detect high‐fidelity HD‐sEMG signals during swallowing.
Weijie Hong, Lin Mao, Kai Lin, Chongyuan Huang, Yanyan Su, Shun Zhang, Chengjun Wang, Daming Wang, Jizhou Song, Zuobing Chen   +9 more
wiley   +1 more source

Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.

Thyroid, 2019
Thyroid hormones have long been known to have a range of effects on the cardiovascular system. However, significant knowledge gaps exist concerning the precise molecular and biochemical mechanisms governing these effects and the optimal strategies for ...
A. Cappola, Akshay S. Desai, M. Medici, L. Cooper, D. Egan, G. Sopko, G. Fishman, S. Goldman, D. Cooper, S. Mora, P. Kudenchuk, A. Hollenberg, Cheryl L. McDonald, P. Ladenson   +13 more
semanticscholar   +1 more source

Thyroid bone disease

Indian Journal of Medical Research, 2012
In this issue Jyotsna et al1 report the changes in bone mineral density (BMD) in predominantly 25(OH)D deficient patients with Graves disease. They have studied the thyroid functions, bone mineral parameters in serum and BMD before and after the achievement of euthyroid status in study group and related the hormonal changes to BMD.
openaire   +3 more sources

The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation–Ubiquitylation Crosstalk of HMGA2

Advanced Science, EarlyView.
Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu, Zhangjin Shen, Shizhen Shen, Conghui Wang, Yuwan Liu, Xinyi Wei, Mengxia Zheng, Jiaxin Gu, Xiaojing Chen, Yi Sun, Junfen Xu, Yan Lu, Weiguo Lu   +12 more
wiley   +1 more source

Iodine Excess as an Environmental Risk Factor for Autoimmune Thyroid Disease

International Journal of Molecular Sciences, 2014
The global effort to prevent iodine deficiency disorders through iodine supplementation, such as universal salt iodization, has achieved impressive progress during the last few decades.
Yuqian Luo, A. Kawashima, Yuko Ishido, A. Yoshihara, Kenzaburo Oda, N. Hiroi, Tetsuhide Ito, N. Ishii, Koichi Suzuki   +8 more
semanticscholar   +1 more source

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source