Results 141 to 150 of about 10,218,078 (407)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Clinical review of the identification and management of infants born to mothers with thyroid disease - is there a role for routine testing of maternal TRAB in the current practice? [PDF]

, 2015
Lucy Malpas
openalex   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study

Clinical Epigenetics
Background Epigenetic age accelerations (EAAs) are a promising new avenue of research, yet their investigation in subacute thyroiditis (SAT) remains scarce.
Bingbing Shen, Yusheng Pu, Xiaofeng Zheng, Yang Liu, Lin Yang, Jiaye Liu, Zhihui Li   +6 more
doaj   +1 more source

Patient satisfaction and operator proficiency in gasless transaxillary endoscopic thyroidectomy under IONM: a retrospective cohort study

Frontiers in Endocrinology
BackgroundThis study aims to evaluate the surgical safety and effectiveness of gasless transaxillary endoscopic thyroidectomy (GTET), assess patients’ short-term perceptions and long-term outcomes, and delineate the learning curve and key surgical ...
Yushuai Zhang, Yushuai Zhang, Yishen Zhao, Yishen Zhao, Hong Tang, Hongrui Zou, Hongrui Zou, Yang Li, Yang Li, Xuehai Bian, Xuehai Bian   +10 more
doaj   +1 more source

Subclinical Thyroid Disease and Mortality in the Elderly: A Retrospective Cohort Study [PDF]

, 2015
Alon Grossman, Avraham Weiss, Nira Koren‐Morag, Ilan Shimon, Yichayaou Beloosesky, Joseph Meyerovitch   +5 more
openalex   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Investigating the impact of STING pathway activation on breast cancer treatment outcomes: development and validation of a prognostic model

Frontiers in Immunology
IntroductionBreast cancer (BRCA) is a significant cause of cancer-associated mortality across the globe. Current therapeutic approaches face challenges such as drug resistance and metastasis. Immune signaling is triggered by chromosomal instability (CIN)
YangYan Zhong, YangYan Zhong, Hong Cao, Hong Cao, Wei Li, Wei Li, Jian Deng, Jian Deng, Dan Li, Dan Li, JunJie Deng, JunJie Deng   +11 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source