Results 141 to 150 of about 9,788,907 (408)

Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Pharmacological Research
Cancer treatment remains a formidable challenge in modern medicine, necessitating a nuanced understanding of its molecular underpinnings and the identification of novel therapeutic modalities.
Liqin Liu, Zhihui Li, Wenshuang Wu
doaj  

RADIOACTIVE IODINE AS AN INDICATOR IN THYROID PHYSIOLOGY. V. THE USE OF RADIOACTIVE IODINE IN THE DIFFERENTIAL DIAGNOSIS OF TWO TYPES OF GRAVES' DISEASE 12 [PDF]

, 1942
S. Hertz, A Roberts
openalex   +1 more source

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

Advanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen, Ke Wang, Lu Liu, Jing Bao, Ming Chen, Xiaowei Qi, Mingxuan Gao   +10 more
wiley   +1 more source

The development of thyroid autoimmunity is potentially associated with the deficiency of vitamin D3 rather than vitamin D2 in euthyroid men

Thyroid Research
Objective Vitamin D(VitD) deficiency has been found prevalent among patients with thyroid autoimmunity (TAI). This study aimed to investigate whether low VitD2 or VitD3 potentially contributed to the development of TAI in euthyroid male patients, which ...
Dongdong Luo, Chenxi Zhang, Bingrui Gao, Deping Wang, Zhaoying Chen, Kan Chen, Bojuan Li, Song Leng, Jing Li   +8 more
doaj   +1 more source

Patient satisfaction and operator proficiency in gasless transaxillary endoscopic thyroidectomy under IONM: a retrospective cohort study

Frontiers in Endocrinology
BackgroundThis study aims to evaluate the surgical safety and effectiveness of gasless transaxillary endoscopic thyroidectomy (GTET), assess patients’ short-term perceptions and long-term outcomes, and delineate the learning curve and key surgical ...
Yushuai Zhang, Yushuai Zhang, Yishen Zhao, Yishen Zhao, Hong Tang, Hongrui Zou, Hongrui Zou, Yang Li, Yang Li, Xuehai Bian, Xuehai Bian   +10 more
doaj   +1 more source

FOUR CASES OF SCLERODERMIA ASSOCIATED WITH DISEASE OF THE THYROID GLAND [PDF]

, 1916
J. H. Sequeira
openalex   +1 more source

The role of the immune system and cytokines involved in the pathogenesis of autoimmune thyroid disease (AITD).

Endokrynologia Polska, 2014
Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disorder. AITD development occurs due to loss of immune tolerance and reactivity to thyroid autoantigens: thyroid peroxidase (TPO), thyroglobulin (TG) and thyroid stimulating ...
H. Mikoś, M. Mikoś, Monika Obara-Moszyńska, M. Niedziela   +3 more
semanticscholar   +1 more source

Use of Best Practice Alerts to Improve Adherence to Evidence-Based Screening in Pediatric Diabetes Care [PDF]

, 2019
Background: Youth with type 1 diabetes (T1D) are at increased risk for comorbid autoimmune conditions and long-term complications. To help with early identification of these complications, the American Diabetes Association (ADA) has published evidence ...
Bartz, Sara K, DeSalvo, Daniel, Mockler, Blair, Sonabend, Rona Y   +3 more
core   +1 more source

Thyroid Diseases

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012
Sri Lanka Journal of Diabetes, Endocrinology and Metabolism 2012; 2: S1-S20 DOI: http://dx.doi.org/10.4038/sjdem.v2i2 ...
Noel Somasundaram, Henry Rajaratnam, Chandrika Wijeyarathne, Shamya De Silva, Channa Ratnathunga, Ranil Fernando, Sisira Siribaddana, Prasad Katulanda, Uditha Bulugahapitiya, Sajith Siyambalapitiya, Charles Antonypillai, Manilka Sumanathilake, Chaminda Garusinghe, Dimutha Muthukuda, MWS Niranjala, Muditha Weerakkody, Dharshini Karuppiah, Sivatharshya Pathmanathan, Sachith Abeyarathne, Shaminda Kahandawa, Samanthi Cooray, Kavinga Gunawardena, Nayananjani Karunasena   +22 more
openaire   +3 more sources

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source