Results 151 to 160 of about 9,788,907 (408)

Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study

open access: yesClinical Epigenetics
Background Epigenetic age accelerations (EAAs) are a promising new avenue of research, yet their investigation in subacute thyroiditis (SAT) remains scarce.
Bingbing Shen   +6 more
doaj   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

open access: yesAdvanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie   +8 more
wiley   +1 more source

Investigating the impact of STING pathway activation on breast cancer treatment outcomes: development and validation of a prognostic model

open access: yesFrontiers in Immunology
IntroductionBreast cancer (BRCA) is a significant cause of cancer-associated mortality across the globe. Current therapeutic approaches face challenges such as drug resistance and metastasis. Immune signaling is triggered by chromosomal instability (CIN)
YangYan Zhong   +11 more
doaj   +1 more source

Prevalence and Risk Factors of Subclinical Thyroid Disease

open access: yesEndocrinology and Metabolism, 2014
Subclinical thyroid disease is defined biochemically by an abnormal thyrotropin (TSH) level and normal serum-free thyroxine level. The prevalence of this condition varies according to the reference range for TSH and geographic or demographic factors ...
Ye An Kim, Y. J. Park
semanticscholar   +1 more source

Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

open access: yesAdvanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma   +14 more
wiley   +1 more source

TRPC5 expression promotes the proliferation and invasion of papillary thyroid carcinoma through the HIF-1α/Twist pathway

open access: yesTranslational Oncology
Objective: This study aimed to investigate the effect of TRPC5 on PTC (papillary thyroid carcinoma) proliferation and invasion. Methods: Immunofluorescence and western blot were used to evaluate the expression of TRPC5 in paraffin sections and clinical ...
Jing Yang   +8 more
doaj  

Estimating the global prevalence of secondary hyperparathyroidism in patients with chronic kidney disease

open access: yesFrontiers in Endocrinology
BackgroundChronic kidney disease (CKD)-related secondary hyperparathyroidism (SHPT) is associated with higher morbidity and death. The goal of this study was to mine the SHPT data already available to do a meta-analysis on the global prevalence of SHPT ...
Yichao Wang   +10 more
doaj   +1 more source

Lymph node metastasis between the sternocleidomastoid and sternohyoid muscle in papillary thyroid carcinoma patients: A prospective study at multiple centers

open access: yesAsian Journal of Surgery, 2021
Background: The lymph nodes between the sternocleidomastoid and sternohyoid muscle (LNSS) are not explicitly mentioned in the 2015 American Thyroid Association and 2008 American Head and Neck Society (AHNS) guidelines, but they are easily overlooked in ...
Linlin Song   +9 more
doaj  

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