Results 151 to 160 of about 9,876,514 (407)

CARCINOMA OF THE SPINE,—A CASE OF CAUDA EQUINA DISEASE FOLLOWING THYROID METASTASIS [PDF]

, 1917
A. SKVERSKY
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The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

TRPC5 expression promotes the proliferation and invasion of papillary thyroid carcinoma through the HIF-1α/Twist pathway

Translational Oncology
Objective: This study aimed to investigate the effect of TRPC5 on PTC (papillary thyroid carcinoma) proliferation and invasion. Methods: Immunofluorescence and western blot were used to evaluate the expression of TRPC5 in paraffin sections and clinical ...
Jing Yang, Yue Cheng, Yan Nie, Bole Tian, Jing Huang, Rixiang Gong, Zhihui Li, Jingqiang Zhu, Yanping Gong   +8 more
doaj  

Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study

Clinical Epigenetics
Background Epigenetic age accelerations (EAAs) are a promising new avenue of research, yet their investigation in subacute thyroiditis (SAT) remains scarce.
Bingbing Shen, Yusheng Pu, Xiaofeng Zheng, Yang Liu, Lin Yang, Jiaye Liu, Zhihui Li   +6 more
doaj   +1 more source

THE COURSE OF ACQUIRED DISEASE OP THE THYROID GLAND AND THE PRINCIPLES WHICH SEEM TO CONTROL ITS PROGRESS [PDF]

, 1914
John Rogers
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Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

Advanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma, Lei Gao, Kewei Song, Baohong Gu, Bofang Wang, Yang Yu, Xueyan Wang, Xuemei Li, Jike Hu, Weigao Pu, Yunpeng Wang, Na Wang, Dedai Lu, Zhijian Han, Hao Chen   +14 more
wiley   +1 more source

Investigating the impact of STING pathway activation on breast cancer treatment outcomes: development and validation of a prognostic model

Frontiers in Immunology
IntroductionBreast cancer (BRCA) is a significant cause of cancer-associated mortality across the globe. Current therapeutic approaches face challenges such as drug resistance and metastasis. Immune signaling is triggered by chromosomal instability (CIN)
YangYan Zhong, YangYan Zhong, Hong Cao, Hong Cao, Wei Li, Wei Li, Jian Deng, Jian Deng, Dan Li, Dan Li, JunJie Deng, JunJie Deng   +11 more
doaj   +1 more source

The Place of Radioactive Iodine in the Treatment of Thyroid Disease [PDF]

, 1957
E. E. Pochin
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In Situ Assembly of Fluorogenic RNA for Screening Natural Anti‐Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA

Advanced Science, EarlyView.
This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai, Li‐Zeng Zhu, Changfa Shao, Zheng Yin, Qun Liu, Yu Gu, Bin Liu   +6 more
wiley   +1 more source

Estimating the global prevalence of secondary hyperparathyroidism in patients with chronic kidney disease

Frontiers in Endocrinology
BackgroundChronic kidney disease (CKD)-related secondary hyperparathyroidism (SHPT) is associated with higher morbidity and death. The goal of this study was to mine the SHPT data already available to do a meta-analysis on the global prevalence of SHPT ...
Yichao Wang, Yichao Wang, Jiaye Liu, Jiaye Liu, Yiqiao Fang, Yiqiao Fang, Shengliang Zhou, Shengliang Zhou, Xueting Liu, Zhihui Li, Zhihui Li   +10 more
doaj   +1 more source