Results 41 to 50 of about 611,083 (309)

Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Pharmacological Research
Cancer treatment remains a formidable challenge in modern medicine, necessitating a nuanced understanding of its molecular underpinnings and the identification of novel therapeutic modalities.
Liqin Liu, Zhihui Li, Wenshuang Wu
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Trends of the prevalence rate of central lymph node metastasis and multifocality in patients with low-risk papillary thyroid carcinoma after delayed thyroid surgery

Frontiers in Endocrinology
BackgroundActive surveillance has been an option for patients with low-risk papillary thyroid carcinoma (PTC). However, whether delayed surgery leads to an increased risk of local tumor metastasis remain unclear.
Pei Wang, Pei Wang, Zhizhong Dong, Shuyan Zhao, Yanjun Su, Jianming Zhang, Yunhai Ma, Chang Diao, Jun Qian, Ruochuan Cheng, Wen Liu   +10 more
doaj   +1 more source

Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading

Frontiers in Immunology, 2017
Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with immunodominant regions on thyroid autoantigens, thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyrotropin receptor (TSHR) A ...
Sandra M. McLachlan, Basil Rapoport
doaj   +1 more source

Diabetes mellitus and insulin resistance associated with Kabuki syndrome—A case report and literature review

Clinical Case Reports, 2022
Kabuki syndrome (KS) is a genetic disorder characterized by distinctive facies, intellectual disability, and multi‐organ anomalies. This case report highlights the importance of clinical recognizable phenotype in patients with diabetes.
Yotsapon Thewjitcharoen, Ekgaluck Wanothayaroj, Soontaree Nakasatien, Sirinate Krittiyawong, Ishant Khurana, Assam El‐Osta, Thep Himathongkam   +6 more
doaj   +1 more source

Identification of Hub lncRNAs Along With lncRNA-miRNA-mRNA Network for Effective Diagnosis and Prognosis of Papillary Thyroid Cancer

Frontiers in Pharmacology, 2021
Long noncoding RNAs (lncRNAs) play important roles in tumorigenesis and progression of different cancers and they have been potential biomarkers for cancer diagnosis and prognosis.
Haiyan Li, Feng Liu, Xiaoyang Wang, Menglong Li, Zhihui Li, Zhihui Li, Yongmei Xie, Yanzhi Guo   +7 more
doaj   +1 more source

Sporadic Medullary Microcarcinoma in a Young Patient - A Rare Case [PDF]

, 2010
Sporadic medullary microcarcinoma of thyroid is a rare disease detected usually in 0.15% of all thyroid malignancy. We report a case of sporadic medullary microcarcinoma (MMC) of thyroid in a 24 year old male presenting as solitary thyroid nodule.
D, Manjunath, K, Amita, M, Abhishek, S, Vijayshankar   +3 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Estimating Global Prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease in Overweight or Obese Children and Adolescents: Systematic Review and Meta-Analysis

International Journal of Public Health, 2021
Objectives: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new terminology updated from non-alcoholic fatty liver disease (NAFLD). We aim to estimate the global prevalence of MAFLD in overweight or obese children and adolescents, by ...
Jiaye Liu, Jiaye Liu, Chunyang Mu, Kewei Li, Han Luo, Han Luo, Yong Liu, Zhihui Li, Zhihui Li   +8 more
doaj   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source