Results 61 to 70 of about 10,218,078 (407)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

TRPC5 expression promotes the proliferation and invasion of papillary thyroid carcinoma through the HIF-1α/Twist pathway

Translational Oncology
Objective: This study aimed to investigate the effect of TRPC5 on PTC (papillary thyroid carcinoma) proliferation and invasion. Methods: Immunofluorescence and western blot were used to evaluate the expression of TRPC5 in paraffin sections and clinical ...
Jing Yang, Yue Cheng, Yan Nie, Bole Tian, Jing Huang, Rixiang Gong, Zhihui Li, Jingqiang Zhu, Yanping Gong   +8 more
doaj   +1 more source

Diabetes mellitus and insulin resistance associated with Kabuki syndrome—A case report and literature review

Clinical Case Reports, 2022
Kabuki syndrome (KS) is a genetic disorder characterized by distinctive facies, intellectual disability, and multi‐organ anomalies. This case report highlights the importance of clinical recognizable phenotype in patients with diabetes.
Yotsapon Thewjitcharoen, Ekgaluck Wanothayaroj, Soontaree Nakasatien, Sirinate Krittiyawong, Ishant Khurana, Assam El‐Osta, Thep Himathongkam   +6 more
doaj   +1 more source

Identification of Hub lncRNAs Along With lncRNA-miRNA-mRNA Network for Effective Diagnosis and Prognosis of Papillary Thyroid Cancer

Frontiers in Pharmacology, 2021
Long noncoding RNAs (lncRNAs) play important roles in tumorigenesis and progression of different cancers and they have been potential biomarkers for cancer diagnosis and prognosis.
Haiyan Li, Feng Liu, Xiaoyang Wang, Menglong Li, Zhihui Li, Zhihui Li, Yongmei Xie, Yanzhi Guo   +7 more
doaj   +1 more source

Total or near-total thyroidectomy versus subtotal thyroidectomy for multinodular non-toxic goitre in adults [PDF]

, 2015
Background Total thyroidectomy (TT) and subtotal thyroidectomy (ST) are worldwide treatment options for multinodular non-toxic goitre in adults.
Arezzo, Alberto, Avenia, Nicola, Barczyñski, Marcin, Cirocchi, Roberto, D'Andrea, Vito, DI ROCCO, Giorgio, Guarino, Salvatore, Randolph, Justus, Santoro, Alberto, Trastulli, Stefano   +9 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Glutamate activates the MAPK pathway by inhibiting LPAR1 expression and promotes anlotinib resistance in thyroid cancer

Discover Oncology
Objective To investigate the effects of glutamate on thyroid cancer (TC) cell lines and TC-anlotinib-resistant cell lines and to explore the potential molecular mechanism of glutamate and LPAR1 in promoting anlotinib resistance in TC.
Bin Liu, Ying Peng, Yanjun Su, Chang Diao, Liansheng Cha, Ruochuan Cheng   +5 more
doaj   +1 more source

Estimating Global Prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease in Overweight or Obese Children and Adolescents: Systematic Review and Meta-Analysis

International Journal of Public Health, 2021
Objectives: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new terminology updated from non-alcoholic fatty liver disease (NAFLD). We aim to estimate the global prevalence of MAFLD in overweight or obese children and adolescents, by ...
Jiaye Liu, Jiaye Liu, Chunyang Mu, Kewei Li, Han Luo, Han Luo, Yong Liu, Zhihui Li, Zhihui Li   +8 more
doaj   +1 more source

Public perceptions of changing the terminology for low-risk thyroid cancer: A qualitative focus group study [PDF]

, 2019
Objectives To investigate public perceptions of overdiagnosis and overtreatment in low-risk thyroid cancer and explore opinions regarding the proposed strategy to change the terminology of low-risk cancers.
Barratt, Alexandra, Brito, Juan P., Jordan, Susan, McCaffery, Kirsten, McLeod, Donald, Moynihan, Ray, Nickel, Brooke, Semsarian, Caitlin   +7 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source