Results 171 to 180 of about 10,941,291 (404)

In Vitro Analysis of the Thyroid Hormone Receptor in Mitochondrial Transcription [PDF]

open access: yes, 2017
The central dogma theory relates how DNA is transcribed into messenger RNA (mRNAs) and then translated into proteins. Since the nucleus contains the majority of the DNA in cells, research related to transcription and translation focuses on these ...
Bestwick, Megan   +3 more
core   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

open access: yesAdvanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen   +6 more
wiley   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang   +13 more
wiley   +1 more source

Prevalence of Thyroid Function Abnormalities and Its Association with Physical Fatigue in First-Year Medical Students

open access: yesInternational Journal of Integrated Health Sciences
Objective: To estimate prevalence and type of thyroid function abnormalities and explore their associations with physical fatigue in first-year medical students.
Arindam Ghosh   +2 more
doaj   +1 more source

Chinese Expert Consensus on Standardized Outpatient Management of Sarcopenia in the Elderly (2024)

open access: yesAGING MEDICINE, EarlyView.
In China, specific sarcopenia clinics are not sufficient for outpatients. This consensus combines the professional advice of domestic geriatrics experts, summarizes the existing domestic experience in the establishment of sarcopenia clinics, and provides guidance for the management of sarcopenia clinics.
Zhang Qin   +78 more
wiley   +1 more source

Effect of Intraoperative Posture on Accurate Diagnostic Rate of Intraoperative Nerve Monitoring During Esophagectomy

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Adequate contact between the intubation tube and the vocal cord muscles is crucial for effective intraoperative nerve monitoring use during esophagectomy. Additionally, intraoperative posture significantly affects diagnostic outcomes and should be carefully considered.
Masami Yuda   +9 more
wiley   +1 more source

Subclinical Thyroid Dysfunction: Diagnosis and Management [PDF]

open access: yes, 2018
Thyroid glands play a critical role in fetal brain development during pregnancy and in the regulation of growth and metabolic function after development.
Antika, L. D. (Lucia)   +1 more
core  

Classification of Pulmonary Nodules Using Multimodal Feature‐Driven Graph Convolutional Networks with Specificity Proficiency

open access: yesAdvanced Intelligent Systems, EarlyView.
The radiomics feature could save the storage space of all medical samples; on the other hand, it avoids data leakage. Graph convolutional neural networks could summarize the similarity of benign and malignant pulmonary nodules to improve the performance in distinguishing them with radiomics and common clinical features.
Renjie Xu   +7 more
wiley   +1 more source

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