Results 151 to 160 of about 214,079 (347)
Advanced Science, EarlyView.This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang +13 more
wiley +1 more source
Spatiotemporal Adaptations‐Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response
Advanced Science, EarlyView.This study uncovers the thyroid hormone receptor Thra as a pivotal regulator that spatiotemporally orchestrates dual‐phase skin repair. Epidermal Thra accelerates barrier restoration via glutathione‐driven keratin assembly, while dermal Thra establishes angiogenic niches through SAA3‐FN1‐mediated matrix remodeling.
Zeming Li +15 more
wiley +1 more source
Advanced Science, EarlyView.This study determines the maximum tolerated dose of lenvatinib in combination with paclitaxel as second‐line therapy for advanced gastric cancer patients. A dynamic network biomarker panel associated with patient prognosis and response to treatment is established.
Chenfei Zhou +8 more
wiley +1 more source
Bioprinted Organoids: An Innovative Engine in Biomedicine
Advanced Science, EarlyView.Bioprinted organoids refer to either the printing of stem cells into tissue shape and subsequent differentiate into organoids, or assembling induced organoids as bioinks to replicate native organ. It enables the creation of miniaturized organs with complex architectures and physiological functions, potentially enhancing reproducibility, throughput, and
Zhengwei Li +11 more
wiley +1 more source
Effect of Valproate Monotherapy on Thyroid Function Tests and Magnesium Levels in Children With Epilepsy. [PDF]
Cureus, 2023 Alhyan P +5 more
europepmc +1 more source
Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis
Advanced Science, EarlyView.Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan +13 more
wiley +1 more source
The impact of covid-19 on thyroid function tests in pregnancy. [PDF]
Endocrine, 2023 Atalay A +7 more
europepmc +1 more source
Levothyroxine effects on depressive symptoms and limbic glucose metabolism in bipolar disorder: a randomized, placebo-controlled positron emission tomography study. [PDF]
, 2016 Adding supraphysiologic doses of levothyroxine (L-T4) to standard treatment for bipolar depression shows promise, but the mechanisms underlying clinical improvement are unknown.
Adli, M +9 more
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