Results 211 to 220 of about 8,604,077 (300)

How to Optimize Healthy Volunteer Screening and Enrolment in Clinical Trials: A Qualitative and Quantitative Approach to Evaluate Processes and Healthy Volunteers' Perceptions

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Healthy volunteers (HVs) are essential for phase I trials, yet their recruitment and screening remain resource‐intensive and ethically complex. High screening failure (SF) rates highlight the need to evaluate and understand all aspects of the enrolment processes. We analyzed SF patterns in a large German HV cohort and explored participants' motivations,
Evelyn Krohmer   +10 more
wiley   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung   +12 more
wiley   +1 more source

Thyroid function tests in overweight and obese children and adolescents with and without non-alcoholic fatty liver disease. [PDF]

open access: yesCaspian J Intern Med
Barzegar A   +6 more
europepmc   +1 more source

Two Pillars of My Path in Cytopathology: Mentorship From Training to Practice

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Mentorship has been a cornerstone of my professional development in cytopathology, shaping both my diagnostic acumen and academic identity. Under the guidance of Dr. Claire Michael during residency and fellowship, I was introduced to a culture of intellectual rigor, systems thinking, and continuous improvement.
Hamza N. Gokozan
wiley   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard   +3 more
wiley   +1 more source

Chemically Modular, Nonfluorinated Polymer Adsorbents for Capturing Per‐ and Polyfluoroalkyl Substances (PFAS)

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Nonfluorinated polymer networks for PFAS adsorption are synthesized using active ester click chemistry. Incorporating Lewis base ligands along with hydrophilic and hydrophobic co‐monomers leads to high PFOA binding efficiency. Ligand basicity and pH are found to play an important role in PFOA sorption.
Lakshay K. Dhamania, Joshua D. Moon
wiley   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai   +2 more
wiley   +1 more source

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