Results 31 to 40 of about 45,394 (248)

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Ultrasound Characteristics of Thyroid Nodules: Differentiating Benign from Malignant Nodules Using Histopathology as the Gold Standard.

Saudi Journal of Radiology
Background: Thyroid nodules are a common clinical finding. Accurate differentiation between benign and malignant nodules is crucial for determining appropriate management and treatment.
Mohammad Khayat, Rayan Halawani, Turki Dhahi, Albaraa Ashour, Raed Alahmadi, Ali Almutairi, Abdullah Alasadi, Ahmed Alharbi, Asrar Aljohani, Jawaher Almowallad, Khaled Alsarrani, Mosleh Aljabri   +11 more
doaj   +1 more source

Automated Segmentation of Thyroid Nodule, Gland, and Cystic Components From Ultrasound Images Using Deep Learning

IEEE Access, 2020
Sonographic features associated with margins, shape, size, and volume of thyroid nodules are used to assess their risk of malignancy. Automatically segmenting nodules from normal thyroid gland would enable an automated estimation of these features.
Viksit Kumar, Jeremy Webb, Adriana Gregory, Duane D. Meixner, John M. Knudsen, Matthew Callstrom, Mostafa Fatemi, Azra Alizad   +7 more
doaj   +1 more source

Prevalence of thyroid nodules and characteristics of thyroid ultrasound in children with goiter: a single center experience

BMC Pediatrics, 2022
Background Goiter is a common presenting sign of various thyroid diseases in children. Thyroid nodules are clinically and/or radiologically significant findings due to their high malignancy rate.
Fahad Al Juraibah, Khalid Al Noaim, Abdulaziz AlDbas, Ahmed AlMuallimi, Omar AlOtaibi, Mozon AlShareef, Alanoud AlSuhibani, Ahmed AlZaharani, Mohammed AlDubayee, Amir Babiker   +9 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Defining Features of Gabriele‐de Vries Syndrome in Adults: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gabriele‐de Vries syndrome (GADEVS) is a neurodevelopmental disorder caused by heterozygous pathogenic variants in the YY1 gene. Like most rare genetic syndromes, the adult manifestations of GADEVS remain poorly defined. Here, we describe the oldest patient reported to date with GADEVS—a 63‐year‐old woman with a c.1177_1179del YY1 variant ...
Ethan W. Hollingsworth, Changrui Xiao
wiley   +1 more source

Comparative ultrasound evaluation of thyroid nodule incidence among diabetics and healthy adults without overt thyroid disease

Sahel Medical Journal, 2017
Background: Diabetes mellitus is associated with increased incidence of thyroid abnormalities, including thyroid nodules and gland enlargement, compared to healthy individuals. Some of these nodules can be malignant.
Ademola A Adeyekun, Christopher C Nduka, Emmanuel O Ighodaro   +2 more
doaj   +1 more source

Evaluation of a Thyroid Nodule [PDF]

Otolaryngologic Clinics of North America, 2010
The thyroid specialist frequently evaluates thyroid nodules because they may represent malignancy. Nodules are typically found on physical examination or incidentally when other imaging studies are performed. Malignant or symptomatic nodules that compress nearby structures warrant surgical excision. Yet, the majority of thyroid nodules are asymptomatic
Steven R, Bomeli, Shane O, LeBeau, Robert L, Ferris   +2 more
openaire   +2 more sources

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source