Results 51 to 60 of about 80,683 (293)

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

A Case Series Study on Thyroid Autotransplantation. [PDF]

Ain-Shams Journal of Surgery
Introduction: Total thyroidectomy is a common surgery nowadays, yet the use of long-life replacement therapyhas its complications. Thyroid autotransplantation helps to reach a euthyroid state with an autoregulatorymechanism of the grafted thyroid tissue ...
Dina Hany, Mohammed Abdelrahman, Ahmed Elhoofy   +2 more
doaj   +1 more source

Destructive thyroiditis secondary to a metastasis

, 2002
A 62-YEAR-OLD CHINESE WOMAN was admitted with a 1 month history of a progressively enlarging left thyroid nodule associated with generalized malaise, weight loss, dysphagia, and vomiting.
Lam, Kin-Yin, Lo, CY, Lo, Chung-Yau, Lam, KY   +3 more
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Thyroid “claw sign” a useful diagnostic marker in the outsized lesions of isthmus: A large colloid cyst.

Radiology Case Reports, 2021
Thyroid isthmus lesions are generally small sized and can be solid or cystic. Discerning isthmic origin of a large nodule, especially if purely cystic, can become a diagnostic challenge because of thin thyroid tissue in it.
Adeena Khan, FCPS, FRCR, MMed, Mamoona Sultan, FCPS, MRCP,FRCP, Waleed Fawzy, MSc, Syed Shahid Habib, MD, FCPS, Muhammad Usman Ul Haq, FCPS   +4 more
doaj   +1 more source

Lithium as an Adjuvant in the Postoperative Ablation of Remnant Tissue in Low-Risk Thyroid Carcinoma

, 2012
Background: Thyroid remnant ablation (RA) with 30 mCi of radioactive iodine (I-131) in patients thyroidectomized for treatment of low-risk differentiated thyroid carcinoma (DTC) has a success rate of 64% to 84%.
Barros Maciel, Rui Monteiro de [UNIFESP], Ikejiri, Elza Setsuko [UNIFESP], Furlanetto, Reinaldo Perrone [UNIFESP], Padovani, Rosalia P. [UNIFESP], Marchetti, Renata Rosa [UNIFESP], Mello Biscolla, Rosa Paula [UNIFESP], Yamazaki, Claudia Akemi [UNIFESP], Matsumura, Luiza Kimiko [UNIFESP], Castiglioni, Mario Luiz V. [UNIFESP]   +8 more
core   +1 more source

3D Large‐Scale Subwavelength‐Resolution Sound Sheet Tomography Based on an Active and Programmable Circular Meta‐Array

Advanced Science, EarlyView.
A programmable 2048‐element circular ultrasound array combined with a compact acoustic lens produces a thin “sound sheet” over a large field of view, and records echoes with wide angular diversity across the ring aperture. Coherence‐enhanced beamforming converts full‐matrix data into high‐contrast tomographic slices, delivering near‐diffraction‐limited
Qiu‐De Zhang, Zi‐Bin Lin, Zhuo Chen, Zhao‐Hui Liu, Jin‐Lian He, Jun‐Jie Song, Long‐Sheng Zeng, Liang Zhou, Ming‐Yue Ding, Yu‐Gui Peng, Ming Yuchi, Xue‐Feng Zhu   +11 more
wiley   +1 more source

Thallium-201 scan in evaluating thyroid nodules following equivocal fine-needle aspiration cytology

, 2006
Summary:The aim of this prospective study was to evaluate the usefulness of the thallium-201 (201Tl) thyroid scan in the detection of malignancy in cold thyroid nodules whose status was equivocal following palpation fine-needle aspiration cytology (FNAC).
W. S. Huang, S. Y. Wu, J. K. Lee, R. S. Liu, M. C. Chou   +4 more
core   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source