Results 221 to 230 of about 100,778 (309)

Malignancy in Pediatric Hyperfunctioning Thyroid Nodules: A Case Report and Literature Review

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Background Thyroid nodules are rare in children but carry a markedly higher risk of malignancy compared to adults (20%–26% vs. 5%). Hyperfunctioning thyroid nodules are exceptionally uncommon in the pediatric population and are typically benign.
Cristina Clausi   +12 more
wiley   +1 more source

Subacute Thyroiditis in Denmark: A Nationwide Study of 1763 Cases

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective Subacute thyroiditis (SAT) is a differential diagnosis in the clinical care of hypo‐ and hyperthyroid patients, but large‐scale population data on the incidence, patient characteristics, and outcome are limited. Thus, the aim was to determine the incidence of SAT in the Danish population and to characterise patient demographics and ...
Marco Juul Thomsen   +5 more
wiley   +1 more source

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas   +11 more
wiley   +1 more source

Real‐World Effectiveness and 12‐Month Persistence of a Semaglutide‐Supported Digital Weight‐Loss Service: A Retrospective Cohort Study in Germany

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To evaluate the 12‐month effectiveness and patient persistence of a semaglutide‐supported digital weight‐loss service (DWLS) in a real‐world German cohort. Methods This retrospective study analysed 4535 patients who initiated the Juniper Germany DWLS. Primary endpoints included 12‐month medication and data submission adherence (receiving ≥ 
Louis Talay   +3 more
wiley   +1 more source

Short‐Term Combined Treatment With Tirzepatide and Metformin for Overweight/Obese Chinese Women With Polycystic Ovary Syndrome: A Prospective, Open‐Label, Randomised Controlled Trial

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study aimed to assess the effects of low‐dose tirzepatide combined with metformin (COM) versus metformin (MET) monotherapy in overweight/obese women with polycystic ovary syndrome (PCOS). Materials and Methods Sixty overweight/obese women with PCOS were randomised to the MET group (1000 mg twice daily [BID]) or the COM group (MET ...
Zhuoran Yang   +7 more
wiley   +1 more source

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