Results 41 to 50 of about 296,723 (312)

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang, Shenglan Li, Liang Wang, Qianxue Chen, Weiguo Hu, Ting Lei, Ying Mao, Jing Zhang, Xiaojun Xiang, Qiming Wang, Zhengwen He, Tao Sun, Yulei Wang, Mengqian Huang, Rong Zhang, Feng Chen, Wenbin Li   +16 more
wiley   +1 more source

Neoadjuvant chemotherapy reduces the levels of HMGB1 and E-cadherin in patients with breast cancer

Scientific Reports, 2023
This study investigated the changes in serum tumor marker levels in patients with breast cancer (BC) after neoadjuvant chemotherapy (NACT) and their potential as prognostic factors in NACT.
Qingchang Su, Xin Wang, Rongchen Zhu, Cuicui Liu, Shanping Sun   +4 more
doaj   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Five crucial prognostic-related autophagy genes stratified female breast cancer patients aged 40–60 years

BMC Bioinformatics, 2021
Background Autophagy is closely related to the progression of breast cancer. The aim at this study is to establish a prognostic-related model comprised of hub autophagy genes (AGs) to assess patient prognosis.
Xiaolong Li, Hengchao Zhang, Jingjing Liu, Ping Li, Yi Sun   +4 more
doaj   +1 more source

Functional radical cervical dissection for differentiated thyroid cancer: the experience of a single center [PDF]

, 2018
There is ongoing debate regarding the role of neck dissection in differentiated thyroid cancer, about its usefulness in elective settings, and the increased costs regarding morbidity and operative time.
Adrian, Tulin, Alecu, Lucian, Cristian, Balalau, Hainarosie, Razvan, Jecan, Radu, Nitipir, Cornelia, Orlov, Cristina, Pantea Stoian, Anca, Pituru, Silviu, Poiana, Catalina, Slavu, Iulian, Tomescu, Luminita, Tulin, Raluca   +12 more
core   +1 more source

Risk stratification of neck lesions detected sonographically during the follow-up of differentiated thyroid cancer [PDF]

, 2016
Context: The European Thyroid Association (ETA) has classified post-treatment cervical ultrasound findings in thyroid cancer patients based on their association with disease persistence/recurrence.
BIFFONI, Marco, Costante, Giuseppe, DURANTE, COSIMO, FILETTI, SEBASTIANO, GIACOMELLI, Laura, GRANI, Giorgio, LAMARTINA, LIVIA, LUPO, STEFANIA, MARANGHI, MARIANNA, plasmati, katia, SPONZIELLO, Marialuisa, TRULLI, FABIANA, VERRIENTI, Antonella   +12 more
core   +1 more source

Risk Factors for Hypoparathyroidism after Thyroid Surgery: A Single-Center Study [PDF]

, 2023
Francesca Privitera, Danilo Centonze, Sandro La Vignera, Rosita A. Condorelli, Costanza Distefano, Rossella Gioco, Alba Ilari Civit, Giordana Riccioli, Ludovica Stella, A Cavallaro, Cannizzaro Ma, Massimiliano Veroux   +11 more
openalex   +1 more source

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Psoralen induced cell cycle arrest by modulating Wnt/β-catenin pathway in breast cancer cells

Scientific Reports, 2018
Psoralen could inhibit the proliferation of human breast cancer cells, however, the molecular mechanism was unclear. We evaluated the anti-proliferative effects of psoralen by MTT, plate colony formation assay and cell cycle analysis in MCF-7 and MDA-MB ...
Xiaohong Wang, Chengfeng Xu, Yitong Hua, Kai Cheng, Yingzhe Zhang, Jian Liu, Yong Han, Song Liu, Guoqiang Zhang, Shujian Xu, Zhenlin Yang   +10 more
doaj   +1 more source

Advances in Conductive Nanomaterials for Cardiac Arrhythmia and Future Directions in Bioevaluation Strategies

Advanced Healthcare Materials, EarlyView.
Conductive nanomaterials (CNMs) show promising potential in cardiac tissue regeneration and restoring cardiac rhythm as reported in several in vitro studies. This review article elaborates on the applications of CNMs in the treatment of myocardial infarction (MI) and MI‐induced cardiac arrhythmias, and it sheds light on the innovative approach of ...
Sumithra Y. Srinivasan, Anna Laromaine
wiley   +1 more source