Results 101 to 110 of about 41,518 (220)
Clinical Endocrinology, Volume 104, Issue 4, Page 372-385, April 2026.ABSTRACT Introduction Over 10 million thyroid function tests (TFTs) are carried out in England each year, most requests coming from primary care. Our previous work showed that only 25% of results for patients being treated with Levothyroxine fell within the TSH/FT4 boundary circumscribing 75% of untreated individuals.
Adrian H. Heald +8 more
wiley +1 more source
Developing a Measure to Assess General Knowledge for Coeliac Disease
Health Expectations, Volume 29, Issue 2, April 2026.ABSTRACT Background The importance of establishing knowledge about coeliac disease relates to the increasing incidence of symptomatic individuals who are undiagnosed. Objectives This study aimed to develop and pilot a tool that could be used to measure general knowledge regarding coeliac disease.
Tiffany Lavis +3 more
wiley +1 more source
Immunology, Volume 177, Issue 4, Page 736-748, April 2026.A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley +1 more source
Clinical heterogeneity in vitiligo: Identification of clinical markers based patient clusters
Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 4, Page 670-679, April 2026.Vitiligo is a chronic autoimmune disease with heterogeneous clinical presentations. This study analysed 399 patients using hierarchical clustering and identified five phenotypes based on clinical characteristics and lesion distribution. Two groups exhibited high disease activity and extensive involvement.
Laura Galissi +8 more
wiley +1 more source
International Journal of Cancer, Volume 158, Issue 6, Page 1654-1665, 15 March 2026.What's new? New antibody‐drug conjugates (ADCs) and immunotherapies have helped expand treatment options for urothelial carcinoma (UC). Clinical trials suggest that the ADC enfortumab vedotin (EV) and the immunotherapeutic agent pembrolizumab, when used in combination, are especially effective against UC.
Dora Niedersuess‐Beke +30 more
wiley +1 more source
Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 633-638, March 2026.ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley +1 more source
An Out‐of‐Place Etiology: Recognizing FMR1 Premutation in the Memory Clinic
Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 607-611, March 2026.ABSTRACT The FMR1 gene premutation (55–200 CGG repeats) is usually associated with a wide range of symptoms and phenotypes within the Fragile X‐tremor/ataxia syndrome (FXTAS), but may also manifest as predominant or isolated cognitive decline. We describe three male patients referred for progressive cognitive impairment and behavioral changes. Standard
Guido Greco +7 more
wiley +1 more source
ACR Open Rheumatology, Volume 8, Issue 3, March 2026.Objective Juvenile dermatomyositis (JDM) is a rare childhood inflammatory myopathy, whereas spondyloarthritis (SpA) is an inflammatory arthropathy characterized by enthesitis and peripheral or axial involvement. We describe a series of patients diagnosed with JDM in childhood who later fulfilled classification criteria for SpA, a sequential phenotype ...
Austen Grooms +3 more
wiley +1 more source
Drug Design, Development and Therapy, 2016 Teresa Esposito,1,2 Jean Marc Lobaccaro,3 Maria Grazia Esposito,4 Vincenzo Monda,1 Antonietta Messina,1 Giuseppe Paolisso,5 Bruno Varriale,2 Marcellino Monda,1 Giovanni Messina1,6 1Department of Experimental Medicine, Section of Human Physiology and ...
Esposito T +8 more
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