Results 41 to 50 of about 7,633 (213)

Severe Thyrotoxicosis Caused by Molar Pregnancy: A Case Report and Review of the Literature

open access: yesCureus, 2023
Severe thyrotoxicosis is an acute and life-threatening state of hyperthyroidism. While it is a rare presentation of hyperthyroidism, it is clinically significant because of its high mortality and necessitates early identification and treatment to reduce the incidence of poor outcomes.
Frasik, Christina   +4 more
openaire   +2 more sources

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

open access: yesActa Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Evaluating the Link Between Thyroid Function Test Results and Levothyroxine Dose in the Management of Hypothyroidism: Can We Improve Dosing Regimes?

open access: yesClinical Endocrinology, Volume 104, Issue 4, Page 372-385, April 2026.
ABSTRACT Introduction Over 10 million thyroid function tests (TFTs) are carried out in England each year, most requests coming from primary care. Our previous work showed that only 25% of results for patients being treated with Levothyroxine fell within the TSH/FT4 boundary circumscribing 75% of untreated individuals.
Adrian H. Heald   +8 more
wiley   +1 more source

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

open access: yesImmunology, Volume 177, Issue 4, Page 736-748, April 2026.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

The Real‐World Safety Profile of Temazepam: A 20‐Year Pharmacovigilance Analysis Based on the Large‐Scale FAERS Database

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
This study aimed to comprehensively characterize temazepam's safety profile by a large‐scale analysis of real‐world data. Most adverse events occur within the first 30 days of treatment. The findings highlighted the need for enhanced clinical vigilance and dynamic.
Zujun Wen, Xiang Liu, Peng Liu
wiley   +1 more source

Altered Dopamine Metabolism and Response to Treatment with Levodopa/Carbidopa in MCT8 Deficiency

open access: yesMovement Disorders, Volume 41, Issue 2, Page 509-514, February 2026.
Abstract Background Allan‐Herndon‐Dudley syndrome (AHDS)/monocarboxylate transporter 8 (MCT8) deficiency is a rare X‐linked encephalopathy caused by SLC16A2 variants, impairing thyroid hormone (TH) transport into the brain. This leads to early central nervous system (CNS) TH deficiency, affecting brain maturation.
Fabio Bruschi   +12 more
wiley   +1 more source

Peri-operative concerns in a patient with thyroid storm secondary to molar pregnancy

open access: yesIndian Journal of Anaesthesia, 2015
Awareness of the presence of thyroid function abnormalities in patients with molar pregnancy is important for its prompt diagnosis and management. We report the development of thyroid storm in the immediate post-operative period in a 25-year-old female ...
Tanvir Samra   +3 more
doaj   +1 more source

GESTATIONAL TROPHOBLASTIC DISEASE IN BASRAH [PDF]

open access: yesThe Medical Journal of Basrah University, 2007
To date few studies have been reported from Basrah regarding Gestational Trophoblastic disease GTD. This study was a clinical observational study done in Basrah at the 4 main obstetric hospitals based on 137 patients with GTD.
Hassna M. Chaied, Zaineb .T. AL Yasin
doaj   +1 more source

Review of the risks and/or benefits of thyroxine treatment in ‘mild’ subclinical hypothyroidism [PDF]

open access: yes, 2013
Subclinical hypothyroidism (SCH) is a form of mild thyroid failure and is a commonly encountered condition in clinical practice. It denotes the presence of a raised serum thyroid stimulating hormone (TSH) and normal serum free thyroid hormone ...
Agius, Rachel
core  

Resistant Thyrotoxicosis due to Graves' Disease in Pregnancy: Case Report and Review of the Literature [PDF]

open access: yesCureus, 2018
The effective management of Graves' disease (GD) during pregnancy is crucial for maternal and neonatal well-being. Conventional treatment of GD during pregnancy includes antithyroid drugs (ATDs) and surgery, ideally during the second trimester.
Linardi, Anastasia   +6 more
openaire   +2 more sources

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